Terbinafine in Fixed Cutaneous Sporotrichosis: A Case Series
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 11
Abstract
ABSTRACT Sporotrichosis is a chronic granulomatous mycotic infection caused by thermally dimorphic fungus, Sporothrix schenckii. The disease is endemic in tropical and subtropical belts throughout the world. In India, it is commonly seen in the Himalayan belt, frequently encountered in gardeners. Infection generally occurs by traumatic inoculation of soil and plants contaminated with the fungus. In humans, the lesions are usually restricted to the skin, subcutaneous cellular tissue and adjacent lymphatic vessels. Disseminated disease occurs when the fungus spreads throughout the body. Itraconazole is regarded as the treatment of choice for patients with most forms of cutaneous as well as extracutaneous sporotrichosis and amphotericin B as the preferred treatment for patients who are severely ill in disseminated mycotic infections. Terbinafine is a synthetic allylamine used as the drug of choice in tinea infections. This article compiles three cases of fixed cutaneous sporotrichosis, proven histopathologically, who were treated with oral terbinafine due to poor response to itraconazole or because of cost factor, with dosage ranging from 250mg/day to 1g/day, given upto six weeks after clinical resolution. The article also highlights the importance of terbinafine as an effective drug for sporotrichosis where there is poor response to itraconazole or affordability may be an issue.
Authors and Affiliations
Shailendra Vikram Jitendra Singh, Romita Bachaspatimayum, Usham Dharmaraja Meetei, Subhalakshmi Devi Akham, Rita Devi Sanjenbam
Keywords
Related Articles
- EP ID EP524668
- DOI 10.7860/JCDR/2018/25315.12223
- Views 60
- Downloads 0
Quantification of Liver Fat with mDIXON Magnetic Resonance Imaging, Comparison with the Computed Tomography and the Biopsy
Introduction: Accurate, non-invasive method of fat estimation is a valuable test for evaluation of diseases with abnormal hepatic fat. Aim: To determine the accuracy of mDixon MR technique in assessment of liver fat over...
Significance of Cytological Diagnosis in Benign Salivary Gland Lesion
ABSTRACT A diffuse, chronic, non-inflammatory, non-neoplastic usually bilateral, enlargement of major salivary glands is termed as Sialadenosis or sialosis. It is an uncommon cause for enlargement of the parotid gland. W...
Clinicomorphological Study of Leiomyoma Associated Endometrial Changes in Correlation with LMP: In a Tertiary Care Hospital in Rural Tamil Nadu
Abstract Introduction: Leiomyomas are benign smooth muscle tumors. They are the single most common cause for hysterectomy in the reproductive and peri-menopausal age group associated with abnormal uterine bleeding. There...
Interlocking Nailing Versus Plating in Tibial Shaft Fractures in Adults: A Comparative Study
Introduction: Tibial diaphyseal fractures are the commonest long bone fractures in adults, most commonly managed by intramedullary interlocking nailing. However, several metaanalysis show that locking plate osteosynthesi...
Carbamazepine Induced Thrombocytopenia
Antiepileptic Drugs (AEDs) are commonly associated with haematological disorders, including anaemia, thrombocytopenia, neutropenia and even bone marrow failure. Fatal disorders like aplastic anaemia are uncommon. On expl...