Testis spectroscopy may predict sperm retrieval rate in men with non-obstructive azoospermia undergoing micro-TESE: A pilot study

Journal Title: Journal of the Turkish-German Gynecological Association - Year 2020, Vol 21, Issue 2

Abstract

Objective: To investigate whether prior testis magnetic resonance spectroscopy predicts the success or failure of micro-dissection testicular sperm extraction (micro-TESE) in patients with non-obstructive azoospermia (NOA). Material and Methods: Nine men with NOA who were scheduled for micro-TESE for the first time, 9 NOA men with a history of previous micro-TESE and 5 fertile men were enrolled. All NOA patients and fertile controls underwent testis spectroscopy. A multi-voxel spectroscopy sequence was used. Testicular signals of choline (Cho), creatine (Cr), myo-inositol (MI), lactate, and lipids were analyzed quantitatively and compared with the results of the micro-TESEs. Results: The most prominent peaks were Cho and Cr in the fertile controls and NOA subjects with positive sperm retrieval in the micro-TESE. A high Cho peak was detected in 87% of the NOA men with positive sperm retrieval. NOA men without sperm at the previous micro-TESE showed a marked decrease in Cho and Cr signals. For positive sperm retrieval in micro-TESE, the cut-off value of Cho was 1.46 ppm, the cut-off value of Cr was 1.43 ppm, and the cut-off value of MI was 0.79 ppm. Conclusion: Testis spectroscopy can be used as a non-invasive screening method to predict the success or failure of micro-TESE.

Authors and Affiliations

Önder Çelik, Şafak Hatırnaz, Aynur Erşahin, Alper Başbuğ, Gonca Yetkin Yıldırım, Vahit Özener, Neslihan Gürpınar, Sudenaz Çelik, Nilüfer Çelik, Tansu Küçük, Cihat Ünlü

Keywords

Related Articles

Significant improvement of laparoscopic knotting time in medical students through manual training with potential cost savings in laparoscopy - an observational study

Objective: Laparoscopy is a standard procedure in operative gynaecology, but laparoscopic simulator training for novices/junior surgeons is not currently well-established. The aims of this study were to demonstrate that...

Influence of evening/night-time birth on maternal/perinatal outcomes in a low-risk population

Objective: To compare maternal and perinatal outcomes between day-time and evening/night-time births in a low-risk population. Material and Methods: The present study had a retrospective and cross-sectional design. The...

Polycystic ovarian syndrome: Environmental/occupational, lifestyle factors; an overview

Polycystic ovary syndrome (PCOS) is a multifaceted disease of women with infertility that has diverse etiologic factors. Some women may have only a few PCOS-linked symptoms or mild symptoms, whereas others will have seve...

Perinatal outcomes of twenty-five human immunodeficiency virus-infected pregnant women: Hacettepe University experience

Objective: To evaluate perinatal outcomes in human immunodeficiency virus (HIV) infected pregnant women in Turkey. Material and Methods: Maternal characteristics, pregnancy complications, laboratory findings including H...

Download PDF file
  • EP ID EP685448
  • DOI 10.4274/jtgga.galenos.2019.2018.0154
  • Views 160
  • Downloads 0

How To Cite

Önder Çelik, Şafak Hatırnaz, Aynur Erşahin, Alper Başbuğ, Gonca Yetkin Yıldırım, Vahit Özener, Neslihan Gürpınar, Sudenaz Çelik, Nilüfer Çelik, Tansu Küçük, Cihat Ünlü (2020). Testis spectroscopy may predict sperm retrieval rate in men with non-obstructive azoospermia undergoing micro-TESE: A pilot study. Journal of the Turkish-German Gynecological Association, 21(2), -. https://europub.co.uk/articles/-A-685448