Tetra-N-Butyl ammonium hydroxide mediated one-pot synthesis of pyrano [2, 3-d] pyrimidinone Derivatives
Journal Title: Iranian Chemical Communication - Year 2017, Vol 5, Issue 1
Abstract
Tetra-N-Butyl Ammonium Hydroxide was used as a catalyst for one-pot, three component condensation reactions consisting of aromatic aldehydes, malononitrile and barbituric acid in ethanol:water solvent system at 60oC. The current method has major advantages like mild reaction conditions with simple operation, high yields, by using a less toxic and lower costlier catalyst. In conclusion, we have explored nicely the synthetic utility of TBAOH as a commercially available, efficient, mild, straightforward, simple, environmentally and economically friendly organo-basic catalyst for the synthesis of diverse Pyrano[2,3-d]pyrimidinone derivatives. Thus we have developed a novel, simple and highly efficient one-pot multicomponent reaction protocol for the synthesis of Pyrano[2,3-d]pyrimidinone derivatives in ethanol:water solvent system.
Authors and Affiliations
Vivekanand B. Jadhav, Mohasim M. Patel
Keywords
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