Th22, Th17.1, Tc17, Tfh and NKTfh lymphocytes in pathogenesis of multiple sclerosis
Journal Title: Annales Academiae Medicae Silesiensis - Year 2019, Vol 73, Issue
Abstract
Multiple sclerosis (MS) is the most common inflammatory-demyelinating disease, its morbidity varies between 2 per 100 000 inhabitants in sub-Saharan Africa to 100 per 100 000 inhabitants in Europe and North America. Despite the unquestionable progress in medicine, MS is still incurable and all that can be done for a patient is to struggle to slow down the inevitable progress of the disease, which eventually will cause disability. Recognizing the detailed immunopathogenesis of MS is probably the only chance for fully effective treatment. Most of the immunological studies of the previous decades focused on the classic sub-populations of T lymphocytes. This review is focused, however, on novel sub-populations – Th22, Th17.1, Tc17, Tfh and NKTfh lymphocytes in the pathogenesis of MS.
Authors and Affiliations
Michał K. Zarobkiewicz, Agnieszka Bojarska-Junak, Wioleta Kowalska, Jacek Roliński
Keywords
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- EP ID EP447489
- DOI 10.18794/aams/83726
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