Thalassemia an update: molecular basis, clinical features and treatment
Journal Title: International Journal of BioMedicine and Public Health (IJBMPH) - Year 2018, Vol 0, Issue 0
Abstract
Thalassemia are a group of inherited blood disorders caused by the decrease or absence of beta-globin chain synthesis will be determined with decrease in erythrocyte hemoglobin, decreased production of erythrocytes and anemia. More thalassemia is inherited as recessive autosomal. According to this fact that which one of the chains are involved, they invide into two type including alpha and beta thalassemia, which each of them including several types. Thalassemia major is more extensive and patient needs to blood transfusion, but thalassemia minor is slight. The most important problem in this patient include iron overload, cardiac arrhythmia, hepatitis, osteoporosis and endocrine disorder however there are typical signs and symptoms of anemia. Treatment including Change of expression and production of HbF, Hematopoietic stem cell transplantation and Maintenance Treatment such as chelators therapy, Induction of fetal hemoglobin production by using Hydroxia urea, use of immunomodulator agents and Molecular Therapy by targeting of genes involving in HbF expression.in this article we review the thalassemia disorder and discuss on molecular basis, clinical features and treatment.
Authors and Affiliations
Kaveh Tari, Pooya Valizadeh Ardalan, Mahnoosh Abbaszadehdibavar, Amir Atashi, Ali Jalili, Maryam Gheidishahran
Keywords
Related Articles
- EP ID EP262280
- DOI 10.22631/ijbmph.2018.56102
- Views 89
- Downloads 0
Role of nutritional supplements in military personnel: a review article
Introduction:Military personnel need to use nutritional supplements to increase physical and mental efficiency and protect against occupational injuries. However, Information is limited about the effectiveness and effici...
Seroepidemiological study of toxoplasmosis in hemodialysis patients of Ahvaz, Southwest of Iran
Introduction: Toxoplasma gondii infects most warm-blooded vertebrates. Because of the immunodeficiency in hemodialysis patients, these individuals are at higher risk for reactivating chronic toxoplasmosis. Thus, the aim...
The relationship between parenting styles with the aggression of their children in sanandaj primary students
Introduction: Aggression is a conscious behavior which its purpose is to exert physical and psychological suffering. In order to reduce this social disorder, we should search the causes in the family as the first and mos...
Self-care behaviors and related factors in chronic heart failure patients
Introduction: Heart failure is a chronic disease that requires special lifelong self-care behaviors.These patients require to have self-care behaviors to confront their disease problems. Therefore, this study was designe...
A comparative study on the effect of the California Book and relative value of services on the costs of hospitalization for common surgeries in selected hospitals of Sanandaj, Iran
Introduction:Tariff determination is one of the important tools for policy making which governments use to intervene in the health market. The aim of this study was to compare California Book effect and relative value of...