The activity of serum beta-galactosidase in colon cancer patients with a history of alcohol and nicotine dependence: preliminary data
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2013, Vol 67, Issue 0
Abstract
Introduction: Beta-galactosidase (GAL) is a lysosomal exoglycosidase involved in the catabolism of glycoconjugates through the sequential release of beta-linked terminal galactosyl residues. The stimulation of activity of exoglycosidases and other degradative enzymes has been noted in cancers as well as in alcohol and nicotine addiction separately. This is the first study to evaluate the activity of the serum senescence marker GAL in colon cancer patients with a history of alcohol and nicotine dependence, as a potential factor of worse cancer prognosis.Material and Methods: The material was serum of 18 colon cancer patients and 10 healthy volunteers. Ten colon cancer patients met alcohol and nicotine dependence criteria. The activity of beta-galactosidase (pkat/ml) was determined by the colorimetric method. Comparisons between groups were made using the Kruskal-Wallis analysis and differences evaluated using the Mann-Whitney U test. Spearman’s rank correlation coefficient was used to measure the statistical dependence between two variables.Results: The activity of serum GAL was significantly higher in colon cancer patients with a history of alcohol and nicotine dependence, in comparison to colon cancer patients without a history of drinking/smoking (p=0.015; 46% increase), and the controls (p=0.0002; 81% increase). The activity of serum GAL in colon cancer patients without a history of alcohol/nicotine dependence was higher than the activity in the controls (p = 0.043; 24% increase).Discussion/Conclusion: Higher activity of beta-galactosidase may potentially reflect the accelerated growth of the cancer, invasion, metastases, and maturation, when alcohol and nicotine dependence coincide with colon cancer. For a better prognosis of colon cancer, alcohol and nicotine withdrawal seems to be required.
Authors and Affiliations
Napoleon Waszkiewicz, Sławomir Dariusz Szajda, Magdalena Waszkiewicz, Aleksandra Wojtulewska-Supron, Agata Szulc, Alina Kępka, Sylwia Chojnowska, Jacek Dadan, Jerzy Robert Ładny, Krzysztof Zwierz, Beata Zalewska-Szajda
Keywords
Related Articles
- EP ID EP67030
- DOI -
- Views 119
- Downloads 0
Rola białek szlaku niedokrwistości Fanconiego w naprawie DNA i utrzymaniu stabilności genomu
The Fanconi anemia (FA) pathway is one of the DNA repair systems involved in removal of DNA crosslinks. Proteins which belong to this pathway are crucial to the protection of genetic information, whereas disturbances in...
The role of ABC transporters of the blood-brain barrier in opioid tolerance development
Opioids constitute an important group of drugs used in chronic pain treatment, e.g. cancer pain. Unfortunately, the development of the organism’s tolerance to the analgesic activity of opioids, the tendency to develop ad...
Salmonella multiphasic flagellar antigen
In the Salmonella antigenic pattern, more than one phase of flagellar antigen is observed. The phase of flagellar antigen depends of the gene which encodes the protein building the filament of flagella. The fliC gene en...
Genetyczne podłoże inteligencji
Inteligencja jako zdolność do postrzegania, analizy i adaptacji do zmian otoczenia jest przedmiotem wielu badań z zakresu psychologii, neurobiologii, a w ostatnim dwudziestoleciu także z zakresu genetyki. Badania nad bli...
Odd- and branched-chain fatty acids in milk fat – characteristic and health properties
This review analyzes the current state of knowledge on odd- and branched-chain fatty acids present in milk fat. Special attention is devoted to the characteristic, synthesis in ruminants, factors affecting their content...