The analysis of the protective feature of Nigella sativa in reducing Carbimazole toxicity including liver and kidney parameters on Albino male rats
Journal Title: Scientific Journal of Medical Research - Year 2018, Vol 2, Issue 5
Abstract
Objective: Carbimazole is widespread drug utilized for treating hyperthyroidism but ,carbimazole usage was associated with adverse on some organs. Also, carbimazole overdose has been linked to nephritis in rats, while , Nigella sativa a medical plant has many antioxidant effects against liver and kidney" toxicity" so , the aim of study was to explore the protective effect of Nigella sativa against carbimazole-induced hepatic and renal toxicity in rats. Methods: The experiment was done on 24 male albino rats in Karbala University /animal house of Pharmacy College for two months period, this work considered the agreement of the animal rights in the college. The rats were divided into four groups, the first group is control which represented healthy animals , the second group is carbimazole group was drenched orally with 1.6 mg/kg/day of carbimazole , the third group was drenched orally with 4ml/kg of Nigella for three days in a week plus l.6 mg/kg/day of carbimazole and last group was drenched 4ml/kg of Nigella for three days per week. The samples of Blood were collected for lab analysis including the liver and kidney functions and tissues were underwent for histopathological evaluation. Results: The study demonstrated significant effect of Nigella in reducing the toxicity of "carbimazole" in both biochemical parameters for liver and kidney ("ALT, AST, ALP, Urea, Creatinine") and in histological section as mentioned below in results. Conclusion: From the results we concluded that Nigella sativa may have protective effect against "carbimazole toxicity".
Authors and Affiliations
Shatha Hussein Kadhim, Amal Umran Musa, Zahraa Abed al-kareem, Moayad Mijbil Ubaid, Noor D. Aziz
Helicobacter pylori CagA antigen detection of gastric infected patients and its association to severity of disease in Iraq
Objective: Helicobacter pylori (H.pylori) is associated with various upper gastrointestinal tract disorders. Many studies have measured anti-cytotoxin-associated gene A (CagA) antibody concentration as signs of CagA anti...
Seroprevalence Comparison among (CMV , Toxoplasma, Rubella) IgM And IgG Ab In Aborted Women In Karbala Province
Objective: The current study aim to investigate the prevalence of CMV, Rubella, Toxoplasma infections among aborted women. Methods: A total of 300 serum samples were collected from aborted women that admitted to Gynecolo...
The Relationship Between Blood Groups And Dermatophytoses Of Men In Karbala City
Objective: The current study aims to investigate of the relationship between dermatophytoses and blood groups in men. Methods: 37 men patients with dermatophytoses who visited the hospitals in the holy province of Karbal...
THE BETA-THALASSEMIA
The thalassemias are hereditary anemias caused by mutations that affect the synthesis of the globin, the protein component of the hemoglobin. Thalassemias produce massive public health problems in many parts of the world...
Isolation of Enteropathogenic Escherichia coli (EPEC) from chronic diarrheal Iraqi Infants
Objective: Detection and Isolation of Enteropathogenic Escherichia coli (EPEC) from Iraqi Infants with chronic diarrhea as a cause of infectious diarrhea among Iraqi Infants. Methods: From March 2016 to September 2017, a...