Hepatitis C virus strategies to evade the specific-T cell response: a possible mission favoring its persistence

Hepatitis C virus (HCV) is a small, enveloped RNA virus. The number of HCV-infected individuals worldwide is estimated to be approximately 200 million. The vast majority of HCV infections persist, with up to 80% of all c...

Genomic determinants of hepatitis C virus antiviral

Hepatitis C virus (HCV) is an important global health problem with an estimated prevalence of more than 170 million infected individuals worldwide. Currently, the standard antiviral therapy, based on pegylated interferon...

Ironing out steatohepatitis

Cardiac metastasis of hepatocellular carcinoma in a young non-cirrhotic patient, to the left ventricle

Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver. 1,2 The most common extrahepatic metastatic sites are lung, abdominal lymph nodes and bone, while its cardiac metastasis is rare. 2,3Metasta...

Effects of a multidisciplinary approach on the effectiveness of antiviral treatment for chronic hepatitis C

Background. Despite the introduction of direct antiviral agents, pegylated interferon remains the mainstay of treatment for chronic hepatitis C. However, pegylated interferon is associated with a high rate of severe adv...