The Antihyperlipidemic Effects of Resveratrol in Rats with Simultaneous Type II Diabetes and Renovascular Hypertension
Journal Title: International Cardiovascular Research Journal - Year 2016, Vol 10, Issue 4
Abstract
Background: Resveratrol has beneficial effects on experimental and clinical hypertension and diabetes. Objectives: This study aimed at examining antidiuretic and antihyperlipidemic effects of resveratrol in rats with simultaneous type II diabetes and endovascular hypertension. Materials and Methods: This study was performed on eight groups of male Spargue- Dawley rats each containing 8 - 10 animals as follows: control, diabetic (induced by streptozotocin and nicotinamide), renovascular hypertensive (induced by placing Plexiglas clips on the left renal arteries), sham, simultaneously hypertensive–diabetic receiving vehicle (distilled water), and 3 simultaneously hypertensive-diabetic groups receiving 5, 10, and 20 mg/kg/day resveratrol. Blood pressure and heart rate were measured weekly and fasting blood glucose, serum cholesterol, triglyceride, and markers of oxidative stress were measured after 4 weeks of treatment with resveratrol vehicle. The data were analyzed using one-way Analysis of Variance (ANOVA) and Duncan’s multiple range tests. Data analysis was done using SigmaStat software and P ≤ 0.05 was considered to be statistically significant. Results: Serum malondialdehyde, systolic blood pressure, heart rate, fasting blood glucose, blood glycated hemoglobin, and serum triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels were significantly higher in the hypertensivediabetic group receiving vehicle compared to the control group (P < 0.05) and treatment with resveratrol significantly reduced these variables (P < 0.05). On the other hand, serum superoxide dismutase, glutathione reductase, and high-density lipoprotein cholesterol levels were significantly lower in the hypertensive-diabetic group receiving vehicle compared to the control group (P < 0.05) and treatment with resveratrol significantly increased these variables (P < 0.05). Conclusions: The findings indicated that resveratrol had antidiabetic, antihypertensive, and antihyperlipidemic effects, which might be partly due to an antioxidant mechanism.
Authors and Affiliations
Masoud Mozafari, Ali Akbar Nekooeian, Mohammad Reza Panjeshahin
Keywords
Related Articles
- EP ID EP395625
- DOI -
- Views 108
- Downloads 0
Diagnostic Value of Strain Rate Imaging by Tissue Doppler in Patients with Suspected Coronary Artery Disease
Background: Strain Rate Imaging (SRI) is a new diagnostic technique. Objectives: The present study aimed to determine the diagnostic value of SRI in detection and localization of coronary lesions in patients with chest p...
Reference Values of Fetal Mechanical PR Interval and Heart Rate- Corrected Fetal Mechanical PR Interval: Influence of Fetal Sex, Heart Rate, Gestational Age, and Maternal Age
Background: Mechanical PR Interval (MPRI) is an important parameter in the fetus as a surrogate for PR interval. Normal values of MPRI have been reported with controversial effects of Fetal Heart Rate (FHR) and Gestation...
Mediation of FOXO3 Gene on Momism of Quercetin against Isoproterenol Induced Cardiotoxicity in H9C2 Cardiomyoblasts
Background: Due to over production of reactive oxygen species, oxidative stress forms one of the major reasons for progression of Cardiovascular Diseases (CVDs) and the associated cardiomyopathies. Thus, controlling thes...
Genetic Analysis of Congenital Heart Disease in Iranian Pediatric Patients
Background: Congenital Heart Disease (CHD) occurs in nearly 1% of newborns due to genetic and environmental factors. There are many genes involved in CHD. Variants of Gap Junction Protein Alpha 1 (GJA1), Zic Family Membe...
Correlation of Fragmented QRS with Right Ventricular Indexes and Fibrosis in Patients with Repaired Tetralogy of Fallot, by Cardiac Magnetic Resonance Imaging
Background: Repair of tetralogy of fallot (TOF) is associated with diffuse myocardial fibrosis. Cardiac magnetic resonance imaging (CMR) can visualize the areas with myocardial fibrosis. Presence of fragmented QRS (fQRS)...