THE APPLICATION OF ULTRASOUND IRRADIATION AS AN ALTERNATIVE METHOD FOR THE PREPARATION OF 99mTc-OCTREOTIDE RADIO COMPLEX
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 9
Abstract
This approach was launched to evaluate the application of ultrasound waves for the preparation of 99mTc-Octreotide radio conjugate sample. The 740MBq (20 mCi) of 99mTc-Octreotide samples were prepared by the boiling water bath (standard) or ultrasound irradiation methods. The stability of samples in normal saline and human serum albumin was investigated. The partition coefficient and protein bonding of samples were determined. The radioisotope analysis was undertaken to assess the biodistribution of radiotracer samples in rats. The data obtained from this approach revealed that the 99mTc-Octreotide samples were successfully prepared by the newly developed technique. Statistically significant differences have not been observed in the stability, partition coefficient and protein bonding of radiotracer samples which were prepared by either of the two above-mentioned. The radioisotope analysis showed that the applied method for radiolabeling did not lead to a significant difference in the biodistribution pattern of radiotracer samples in rats. Green chemistry can be recommended for the radiolabeling of Octreotide with 99mTc as an alternative and reliable modality for the boiling water bath method.
Authors and Affiliations
A. Doroudi et al.
Keywords
Related Articles
- EP ID EP627215
- DOI 10.13040/IJPSR.0975-8232.10(9).4176-85
- Views 68
- Downloads 0
A COMPREHENSIVE REVIEW OF ALBIZIA PROCERA (ROXB.) BENTH.-AN UPDATE
Albizia procera is a genus of albizia, the member of legume family (fabaceae) and subfamily Mimosoideae. Albizia procera is tree with open canopy, occurs naturally in a wide distribution from India and Myanmar through So...
PROTECTIVE EFFECT OF PERILLYL ALCOHOL (POH) A MONOTERPENE: ON HIGH FAT DIET INDUCED HYPERLIPIDEMIA IN ALBINO WISTAR RATS A PRELIMINARY STUDY
To assess the effect of Perillyl alcohol (POH) on the lipid profile of high-fat-diet-induced hyperlipidemia in white male albino Wistar rats, the hyperlipidemia was induced by feeding cholesterol-rich high-fat diet for 4...
IN-VIVO ROENTGENOGRAPHIC EVALUATION OF COLON TARGETED 5-FLUOROURACIL PELLETS
Objective: This study was an attempt to explore the latent of colon specificity approach utilizing pH-sensitive and time-dependent characteristics of polymers for defined colonic release of 5-Fluorouracil (5-FU). Method:...
EFFECT OF PIPER NIGRUM (LINN.) ON INFERTILITY INDUCED BY ETHIONAMIDE AND PARA AMINO SALICYLIC ACID IN MALE SPRAGUE-DAWLEY RATS
Tuberculosis is a global problem. The tuberculosis is the common cause of male infertility in developing countries due to the use of second-line anti-tuberculosis drugs (ATB). The experiments were conducted at Unique Bio...
ANALYSIS OF TARAXEROL AND TARAXASTEROL IN HAIRY ROOT CULTURES OF TARAXACUM OFFICINALE WEBER
Taraxacum officinale (TO) Weber commonly known as dandelion has contained triterepenes-taraxasterol and taraxerol in its roots which are nowadays being recognized as potent anticancer compounds. The main objective behind...