The Association between Helicobacter Pylori Infection and Parkinson's Disease: A Case-Control Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 10
Abstract
ABSTRACT Introduction: Conflicting results have been reported about the association between Helicobacter pylori infection and Parkinson's disease. Aim: To evaluate the relation between H. pylori infection and Parkinson's disease in patients living in northern Iran. Materials and Methods: In this case-control study, 99 consecutive patients with Parkinson's disease visiting a Neurology Clinic were included. Also, 297 controls were chosen from the participants of the Amirkola Health and Ageing Project, who were matched to the patients with Parkinson's disease for sex, age and educational level. H. pylori infection was assessed by IgG Enzyme-Linked Immunosorbent Assay. The severity of Parkinson's disease was assessed by using the Unified Parkinson's Disease Rating Scale (UPDRS) and the Hoehn and Yahr Scale (HYS). Results: A rate of 66.7% (n=33) of the patients with Parkinson's disease were positive for H. pylori infection, while it was 79.5% (n=236) in the controls {Odds Ratio (OR)=0.52, 95% Confidence Interval (CI)=0.31-0.86, p=0.01}. Scores of UPDRS and HYS were less in H. pylori-positive Parkinson's disease patients than in those who were not infected, however, the differences were not significant. Conclusion: The results of this study suggest that H. pylori infection may protect people from Parkinson's disease. More definitive studies are necessary to confirm this finding.
Authors and Affiliations
Tahereh Babajani Roshan, Ali Bijani, Seyed Reza Hosseini, Mojgan Bagherzade, Payam Saadat, Mohammad Zamani
Keywords
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- EP ID EP526643
- DOI 10.7860/JCDR/2018/37178.12088
- Views 57
- Downloads 0
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