The Association between Helicobacter Pylori Infection in Subjects with Gastritis and Serum Levels of LL-37, MBL and M-Ficolin
Journal Title: Acta Facultatis Medicae Naissensis - Year 2018, Vol 35, Issue 3
Abstract
Helicobacter pylori (H. pylori) can stimulate immune responses and lead to the release of proinflammatory factors and antimicrobial peptides as LL-37, mannose-binding lectin (MBL) and M –ficolin. The aim of this study was to determine the level of changes in serum levels of the three mentioned factors in people with gastritis and their association with the presence or absence of H. Pylori. Subjects were divided into two groups of 35 gastritis individuals with H. pylori and 25 individuals without H. pylori. Biopsy and blood samples were collected from each subject. H. pylori positivity was investigated regarding the serum level by enzyme-linked immunosorbent assay (ELISA) kit and its presence in the tissue was examined by histopathology observations and rapid urease test (RUT). LL-37, MBL and M-ficolin serum levels indicated that 58% of the subjects were infected with H. pylori. Subjects with MBL levels lower than 500 ng/mL in the sera were significantly infected with H. pylori, and subjects with MBL levels higher than 1000 ng/ml often did not have H. pylori infection. The level of LL-37 was increased, while M-ficolin showed no significant change in the presence of H. pylori. Findings indicated that lower levels of MBL and higher levels of LL-37 might be involved in H. pylori infection, while M-ficolin seems to be less effective in the infection.
Authors and Affiliations
Mehdi Soltanzadeh-Yamchi, Javad Shokri-Shirvani, Soheil Ebrahimpour, Mousa Mohammadnia-Afrouzi, Soraya Khafri
Keywords
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- EP ID EP398635
- DOI 10.2478/afmnai-2018-0019
- Views 78
- Downloads 0
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