The Association between Prolonged Jaundice and TATA Box Dinucleotide Repeats in Gilbert’s Syndrome
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 9
Abstract
Introduction: Jaundice is a common condition during the neonatal period. Prolonged jaundice occurs in a large number of breastfed infants, considering the impact of genetic factors on the incidence of jaundice. Aim: To determine the association between prolonged jaundice and TATA box dinucleotide repeats in Gilbert’s Syndrome (GS). Materials and Methods: In this case-control study, the case group consisted of 51 neonates with jaundice, aged more than two weeks with indirect bilirubin level higher than 10 mg/dl. Acute diseases, mother’s use of phenobarbital and other medications were the exclusion criteria. The control group consisted of 54 newborns without jaundice. The two groups were matched in terms of age and sex. TATA box polymorphisms in the promoter region of UGT1A1 gene were evaluated using Polymerase Chain Reaction (PCR) in order to determine TATA box dinucleotide repeats. Results: Overall, 64.7% and 50% of subjects in the case and control groups were male, respectively (p=0.168). The mean age of neonates in the case and control groups was 20.1±7.1days and 18.8±4.1 days, respectively. The distribution of Gilbert genome was not significantly different between the two groups. In the case group, 13.7% of the subjects were homozygous, 37.3% were heterozygous and 49% were normal. In the control group, 7.4% of the participants were homozygous, 35.2% were heterozygous and 57.4% were normal. Conclusion: The results of this study showed an association between TATA box polymorphism and prolonged jaundice in neonates which revealed that TATA box polymorphism is an important risk to increase and extend icterus.
Authors and Affiliations
Yadollah Zahed Pasha, Mousa Ahmadpor Kacho, Haleh Akhavan Niaki, Mehdi Tarighati, Ehsan Alaee
Keywords
Related Articles
- EP ID EP362951
- DOI 10.7860/JCDR/2017/19376.10597
- Views 58
- Downloads 0
An Unusual Radiographic Presentation of Aneurysmal Bone Cyst of the Zygoma: A Rare Case Report
Aneurysmal Bone Cyst (ABC) is an uncommon benign lesion affecting mainly the long bones and vertebral column. Its occurrence in the maxillofacial skeleton is rare. So far only five cases of ABC in the zygoma have been re...
Hypertension in Asymptomatic, Young Medical Students with Parental History of Hypertension
Introduction: Family history of hypertension in medical students is an important, non-modifiable risk factor for hypertension in future. Aim: To determine the prevalence of sustained hypertension in young asymptomatic me...
Neglected Necrotizing Fasciitis - A Rare Complication of Spinal Anaesthesia
Necrotizing Fasciitis (NF) is a rare, rapidly progressive severe bacterial soft tissue infection with a high mortality rate. NF classically involves the trunk, groin/perineum, lower limbs, and postoperative wound sites....
Chronic Unresolved Haematoma of Thigh with Acute Expansion- Emulating Neoplasm
Chronic haematoma formation and its acute expansion are rare in clinical scenario. Its clinical presentation may simulate to malignant soft tissue lesion. Usually they remain inactive for long time but sometimes shows su...
A Rare Case of Ileocecal Tuberculosis with Pulmonary Embolism and Deep Vein Thrombosis
Venous thromboembolism in tuberculosis is not a well recognised entity. It is a less frequently reported complication of severe pulmonary tuberculosis. It is exceedingly rare when it complicates extrapulmonary tuberculos...