THE BACTERIAL PROFILE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF URINARY ISOLATES IN A TERTIARY CARE HOSPITAL IN WESTERN U.P.
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 78
Abstract
BACKGROUND Urinary tract infection (UTI) is one of the common infections in the Indian community. Distribution and susceptibility of UTIcausing pathogens change according to time and place. UTI is one of the most common clinical conditions in patients presenting to the hospitals. Isolation of common pathogens and their antimicrobial susceptibility pattern is important for the adequate treatment. The aim of this study is to determine the bacterial profile and antibiotic susceptibility pattern among pathogens isolated from patients having UTI. MATERIALS AND METHODS A descriptive prospective study of 325 patients suspected with urinary tract infection was processed from January 2016 to June 2016 at a tertiary care hospital according to the standard protocol. Clean-catch mid-stream urine samples were collected in sterile container from urinary tract infected patients. The antibiotic susceptibility of the isolated pathogens was tested by the modified Kirby-Bauer’s disc diffusion antimicrobial test as per the CLSI guidelines. Standard inoculums adjusted to 0.5 McFarland was swabbed on Mueller-Hinton agar and was allowed to soak for 2 to 5 minutes. After that antibiotic disks were placed on the surface of media and pressed gently. Mueller-Hinton agar plates were then incubated at 37°C for 24 h. After 24 h, the inhibition zones were measured and interpreted by the recommendations of clinical and laboratory standards. RESULTS Out of 325 urine samples tested, 71 were found to be positive for microbial isolates of which 46 (25.55%) samples were from female and 25 (17.24%) were from males. The most common isolated organism was Escherichia coli (30.98%). Quinolones (ciprofloxacin and levofloxacin) were sensitive for gram-negative isolates, while gram-positive isolates were sensitive to linezolid, erythromycin and quinolones. CONCLUSION Antibiotic selection should be based on knowledge of prevalence of the local pathogens and antibiotic susceptibility rather than on universal guidelines.
Authors and Affiliations
Kiran Yadav, Gunjan Dutta, Amit Kumar Sah
Keywords
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- EP ID EP268034
- DOI 10.14260/jemds/2017/1200
- Views 85
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