Abstract

Objective: The present investigation is aimed to carry out the behavioural changes of the Mucuna pruriens extract (MPE) and Mucuna pruriens Goldnanoparticles (MPGNPs) against MPTPinduced neurotoxicity. Methods: MPGNPs prepared from the methanolic extract of Mucuna pruriens seeds using Chloroauricchloride (HAuCl4). The seed powder has been found to show the anti-parkinsonian effects. Mice were induced with 10 mg/kg of MPTP, four injections i.p., at 1 h intervals within 24 h. MPE was administered at the dose 200 mg/kg (i.p) and MPGNPs was administered at different doses of 500 毺 g/kg, 5, 10 and 20 mg/kg (i.p) in different groups once a day for seven days and the dose on the first day was given 30 min prior to first MPTP injection. Results: The behavioural changes were studied using the rotarod test, hang test and narrow beam test. MPE and MPGNPs significantly (P<0.05) improved the behavioural activities. Conclusions: MPGNPs possesses significant behavioural activity than MPE against MPTP induced neurotoxicity

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