The Beneficial Effects of Methanol Extract of Annona Muricata Seeds on Acute Hemolytic Anemia in Albino Wistar Rats
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 5
Abstract
The effect of methanol extract of annona muricata seed on packed cell volume, hemoglobin concentration, red cell count, alanine and aspartate aminotransferases, and alkaline phosphatases was investigated using albino wistar rats. Acute hemolytic anemia was induced with phenylhydrazine. The rats packed cell volume was used to determine anemia. Only rats that exhibited anemia were used. They were treated with annona muricata extract for four weeks and these hematological and liver enzymes were investigated. The results showed that extract caused a significant increase in packed cell volume, hemoglobin concentration, and red cell count (P < 0.05), but caused a fall in alanine and aspartate aminotransferases, and alkaline phosphatases (P < 0.05) back to normal. The histopathological studies showed absence of and/or mild liver congestion and inflammation after treatment with extract.The results suggest that annona muricata seed extract is beneficial in the treatment of hemolytic anemia induced liver injury.
Authors and Affiliations
Agbai Emmanuel Onuka
Keywords
Related Articles
- EP ID EP205890
- DOI -
- Views 180
- Downloads 0
Clinico-Haematological Analysis of Pancytopenia in Adults
Background: Pancytopenia is a relatively common hematological entity. It is a striking feature of many serious and life threatening illnesses. The severity of pancytopenia and the underlying pathology determine the manag...
Tracheal Reconstruction Using Pericardium in Emergency as a Life Saving Procedure in Cases of Severe Tracheal Stenosis
Background: Post intubation tracheal stenosis followed by tracheostomy resulting in destruction of long segment of trachea remains a serious clinical problem. In this study we review our experience with technique of trac...
Clinical Correlation between McISSAC Score and Throat Swab Culture In Predicting Streptococcal Pharyngitis In Patients Presenting With Sore Throat
Introduction: GAS pharyngitis is both antecedent for invasive streptococcal infection and post infectious immunologic complication of Rheumatic fever/RHD, a leading cause of cardiovascular morbidity and mortality in many...
Role of Exchange Transfusion In Dapsone Poisoning
Suicidal ingestion of Dapsone can lead to severe methemoglobinemia. Exchange Transfusion decreases Meth-Hb level. We present a young female with suicidal ingestion of Dapsone who responded to Exchange Transfusion
Diagnostic Efficiency of Cell Block Method over Conventional Smear Method in the Cytology of Malignant Effusions– A Prospective Study
Background: Cytological examination of body fluids has increasingly gained acceptance in clinical medicine to such an extent that a positive diagnosis made is often considered definitive diagnosis. It is of utmost import...