The Beneficial Effects of Methanol Extract of Annona Muricata Seeds on Acute Hemolytic Anemia in Albino Wistar Rats
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 5
Abstract
The effect of methanol extract of annona muricata seed on packed cell volume, hemoglobin concentration, red cell count, alanine and aspartate aminotransferases, and alkaline phosphatases was investigated using albino wistar rats. Acute hemolytic anemia was induced with phenylhydrazine. The rats packed cell volume was used to determine anemia. Only rats that exhibited anemia were used. They were treated with annona muricata extract for four weeks and these hematological and liver enzymes were investigated. The results showed that extract caused a significant increase in packed cell volume, hemoglobin concentration, and red cell count (P < 0.05), but caused a fall in alanine and aspartate aminotransferases, and alkaline phosphatases (P < 0.05) back to normal. The histopathological studies showed absence of and/or mild liver congestion and inflammation after treatment with extract.The results suggest that annona muricata seed extract is beneficial in the treatment of hemolytic anemia induced liver injury.
Authors and Affiliations
Agbai Emmanuel Onuka
Keywords
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