THE BIO TOXICITY OF IN-SITU SYNTHESIZED CARBOXYLATED NANODIAMOND-IRON OXIDE NANOCOMPOSITE
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2019, Vol 6, Issue 6
Abstract
Nanodiamond (ND) particles have potential applications in protein immobilization, biosensors, therapeutic molecule delivery and bio imaging. A nanocomposite comprises both high hardness of nanodiamond (ND) and high magnetism of iron oxide (Fe3O4). However, the limited information is available in literature on the in-situ synthesis of biocompatible magnetic materials and also on their potential biotoxicity as a result of their entry into environmental compartments. In this work, it was synthesized a new kind of bio-compatible magnetic material - carboxylated nanodiamond (cND) and iron oxide (Fe3O4) to obtain the cND-Fe3O4 nanocomposite, which was produced by in-situ and chemical reduction of Fe3+ and Fe2+ cations on the acid treated nanodiamond surface by sodium hydroxide. The synthesized cND-Fe3O4 nanocomposite was characterized by XRD, SEM, TEM and VSM. The cyto-genotoxicity of the synthesized nanocomposite material was studied by using Garlic (Allium Sativum L). as a test model with concentrations of 5, 10 and 20 μg/ml. The study was also extended to cND and Fe3O4 materials for comparison purpose. The Fe3O4 and cND exhibited their contrasting effects on mitosis and other cyto-genotoxic indices studied herein. This work provided fundamental data on the synthesis and the biotoxicity of cND-Fe3O4 nanocomposite, which, in turn, can help to expand their multidisciplinary applications.
Authors and Affiliations
Dr. B. Chandra Sekhar Singh
Keywords
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