THE BIOPHARMACEUTICAL CLASSIFICATION SYSTEM (BCS): PRESENT STATUS AND FUTURE PROSPECTIVES  

Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 9

Abstract

The Biopharmaceutical classification system (BCS) was introduced By Amidon et al., (1995) as a method for classifying drug substances based on their dose/solubility ratio and intestinal permeability. It allows predicting the in vivo pharmacokinetic performance of drug products. The drug can be categorized into four classes of BCS, namely, High solubility high permeability, low solubility high permeability, High solubility low permeability and low solubility low permeability. An objective of BCS approach is to determine the equilibrium solubility of drug substances under physiological environment. The BCS helps in mathematically analyzing the kinetics and dynamics of drug in gastrointestinal tract (GIT) for New Drug Applications (NDA) and Abbreviated New Drug Applications (ANDA) filings and biowaivers. This step reduces time in the new drug development process. Further it helps to decide when the dissolution rate is likely to be the rate determining step. It also helps in the prediction of potential of inactive ingredients in the dosage form to alter the dissolution / absorption of the drug. The present review, apart from giving a brief overview of BCS classification system, highlights these and some of the more recent applications of BCS classification system. 

Authors and Affiliations

Vikaas Budhwaar , Arun Nanda

Keywords

Related Articles

PHARMACOGNOSTIC EVALUATION AND PRELIMINARY PHYTOCHEMICAL SCREENING ON THE LEAVES OF XIMENIA AMERICANA LINN. 

The Present communication deals with the various pharmacognostic evaluation on the leaves of Ximenia americana include morphological, microscopical characters, powder microscopy and physicochemical characters like ash va...

ANITIDIABETIC, ANTIHYPERLIPIDAEMIC AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACT OF FERONIA ELEPHANTUM CORREA LEAF AND BARK IN NORMAL AND ALLOXAN INDUCED DIABETIC RATS  

The aim of the present study was to evaluate the antidiabetic Potential of ethanol extract of Feronia elephantum Correa leaf and bark in normal and alloxan induced diabetic rats. Diabetes was induced in Albino rats by ad...

ANALYSIS OF PRESCRIPTION PATTERN AND DRUG UTILIZATION IN ASTHMA THERAPY  

This drug utilization or prescription-monitoring study was conducted to evaluate the drug-prescribing trend of anti-asthmatic drugs in retailed pharmacy outlets during 2009 and 2011 in urban and rural area of Saurashtra...

A CLINICAL STUDY ON THE EFFICACY OF WHEAT GRASS JUICE IN PRAMEHA 

It is a clinical study conducted on patients of Prameha (Madumeha) nearest resembling condition with diabetes mellitus, a rich man’s disease. Present study was planned with an aim and objectives. To evaluate the hypoglyc...

CHEMOPREVENTIVE POTENTIAL OF CARALLUMA ADSCENDENS (ROXB.) AGAINST 1,2 DIMETHYL HYDRAZINE INDUCED COLON CARCINOGENESIS  

Colorectal cancer is increasingly common nowadays in Asian countries and still remains the second leading cause of cancer death in the United States. The chemopreventive and hypolipidemic effect of Caralluma adscendens (...

Download PDF file
  • EP ID EP119799
  • DOI -
  • Views 123
  • Downloads 0

How To Cite

Vikaas Budhwaar, Arun Nanda (2012). THE BIOPHARMACEUTICAL CLASSIFICATION SYSTEM (BCS): PRESENT STATUS AND FUTURE PROSPECTIVES  . International Research Journal of Pharmacy (IRJP), 3(9), 7-11. https://europub.co.uk/articles/-A-119799