THE CARDIO-PROTECTIVE \"PARAOXONASE-1\" AS A VALUABLE PROMISING TOOL IN DIAGNOSIS AND/OR ASSESSMENT OF CARDIOVASCULAR RISK IN TYPE 2 DIABETES.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 10
Abstract
Background: Type 2 Diabetes Mellitus \\\\\\\"T2D\\\\\\\"remains frequently undiagnosed for many years; as the hyperglycemia is often not severe enough to provoke noticeable symptoms. Thus, such patients are at increased risk of developing macrovascular and microvascular events. Diabetic cardiovascular \\\\\\\"CVD\\\\\\\" complications are one of the most leading causes of death worldwide. Prevention of long-term chronic complications has become one of the main goals of modern treatment in T2D. However, new tools are still needed for early detection or even prediction of CVD risk to facilitate decreasing morbidity and mortality rates associated with T2D. Objectives:In this study, authors aimed to afford access to information that may allow early detection &/or prediction of macrovascular complications in Egyptian patients with T2D. Subjects and Methods:The study included200 clinically diagnosed T2D patients (subdivided according to presence of CVD complication). In addition, 60 healthy controls were selected with comparable socioeconomic, age, body mass index, and sex distribution. Inclusion and exclusion criteria were applied. Glycemic control indices, lipid profile, Paraoxonase-1, MCP-1, ICAM-1, VCAM 1, and Lp (a) were measured. Results were statistically analyzed. Results: Serum levels of Paraoxonase-1 (↓),MCP-1 (↑), ICAM-1 (↑), VCAM 1 (↑), and Lp (a) (↑) were altered significantly in both diabetic cohorts compared to healthy controls. Also, Paraoxonase-1 (↓↓), MCP-1 (↑↑), ICAM-1 (↑↑), VCAM 1 (↑↑) levels showed significant alteration in T2D patients with CVD compared to those without complication. Additionally, with respect to prediction of CVD risk, results predict that Paraoxonase-1 has higher and better diagnostic accuracy index as indicated by ROC analysis. Conclusion: Paraoxonase-1 is a sensitive biomarker in T2D with anti-atherogenic cardio-protective properties; its circulating levels may be a valuable future tool for early diagnosis and/or assessment of CVD risk associated with T2D.
Authors and Affiliations
Ahmed M. A. Akabawy, Heba I. Hamed, Wafaa S. Hegab, Naglaa F. Mohamed.
Keywords
Related Articles
- EP ID EP409432
- DOI 10.21474/IJAR01/7783
- Views 57
- Downloads 0
CULTURAL GENOCIDE - A GENOCIDAL TECHNIQUE AGAINST CHILDREN: AN UNDERSTANDING THROUGH INTERNATIONAL CRIMINAL JUSTICE SYSTEM.
Any violation of human rights under the international humanitarian law is serious crimes under international criminal justice system. Any actions that shocks the conscience of international community will be answered thr...
ANALYSIS OF URBAN GROWTH AND SPRAWL AND BUILT UP DENSITY USING REMOTE SENSING DATA: CASE OF CASABLANCA, MOROCCO.
In Casablanca, the rate of population growth has been spectacular in recent years according to the 2014 National population census. The city has a population of 3.35 million in the urban area and over 4.27million on the...
IMPACT OF PRIOR WORK EXPERIENCE ON ENTREPRENEURIAL INTENTION AND THEORY OF PLANNED BEHAVIOR IN CONTEXT OF PAKISTAN.
The present study aims to investigate the impact of prior work experience influence on the entrepreneurial intention in the context of Pakistan. Where 58% population lies in the age of 20-30 years, 45 % people hold maste...
LA LEISHMANIOSE VISC?RALE AU COURS DU LUPUS ?RYTH?MATEUX SYST?MIQUE, UNE NOUVELLE OBSERVATION AVEC REVUE DE LA LITT?RATURE.
La leishmaniose visc?rale est une forme particuli?rement grave de l?infection par les parasites intracellulaires du genre Leishmania. Bien que c?est une affection immunod?primante, la survenue de la leishmaniose au cours...
DEVELOPMENT OF COUNSELING MODEL OF DERADICALIZATION PROGRAM IN INDONESIA: ALTERNATIVE FOR INTEGRATIVE COUNSELING MODEL FOR TERRORISM PRISONERS AS AN EFFORT TO PREVENT AND ERRADICATE THE CRIME OF TERRORISM IN INDONESIA.
The rise of the issue of the radicalism movement in Indonesia recently has made the Indonesian government necessary to review the strategies and efforts that have been made in order to quell the turmoil of radicalism. th...