The Cell Based Model of in-vivo Coagulation: A Work in Progress
Journal Title: International Blood Research & Reviews - Year 2016, Vol 6, Issue 1
Abstract
The goal of this article is to review the evolution of theories of coagulation and their proposed models to serve as a tool. When reviewing the research and practice literature that was published in the context of these theories over time, including the critical contribution of cells, we have observed a model based on work of many workers, in which Hemostasis is regulated by various properties of cell surface, which occurs in vivo. The coagulation occurs not as a cascade/waterfall, but occurs in 4 overlapping steps-(i) Initiation, (ii) Amplification, (iii) Propagation, (iv) Termination. Cell Based model has given an insight into the pathophysiological mechanism of certain coagulation disorders which were till now ill understood.
Authors and Affiliations
Anubhav Abinash Sahu, Biswaprakash Patri, Souravi Pal, Sukumar Chakravarty
Keywords
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- EP ID EP242642
- DOI 10.9734/IBRR/2016/26906
- Views 95
- Downloads 0
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