The circadian rhythm of glycosylated compounds: HOMA-R and HOMA-β
Journal Title: Journal of Analytical Bio-Science - Year 2012, Vol 35, Issue 5
Abstract
Although there is some difference among an individuals, it is well known that circadian changes are present in nearly all life throughout our bodies. It is important to understand interindividual variations in order to distinguish them from morbidity. Data were obtained from 10 healthy volunteers (5 males: ages 37.5±6.5 years, 5 females: ages 41.5±14.5 years). Blood specimens were collected every 2 hours, and blood glucose and IRI (immunoreactive insulin) were measured. We evaluated the within-subject biological variations of glycosylated compounds. In this study, we attempted to identify the optimal drawing blood time for the calculation of an insulin resistance index (homeostasis model assessment ratio: HOMA-R and homeostatic model assessment beta cell function: HOMA-β).
Authors and Affiliations
Akemi Matsubara
Keywords
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