The Clinical Course of Late Diagnosed Fatal Cases of A (H1N1) Influenza in Poland
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2013, Vol 67, Issue 0
Abstract
Introduction: The most frequent complication of A (H1N1) influenza and the leading cause of death was pneumonia with a primary viral or mixed viral and bacterial etiology. 182 patients had died because of a pandemic influenza in Poland by 31st July 2010.Material and Methods: A retrospective study of 6 fatal cases of pandemic influenza, aged 23-41, including 3 women, hospitalised between November 2009 and February 2011 in different Polish medical centres.Results: We present the clinical course of 6 late diagnosed cases of A (H1N1) influenza. All patients presented typical flu-like symptoms in the beginning. 4/6 patients had severe disease risk factors: pregnancy, arthritis, Wegener granulomatosis and obesity. All patients were seen by doctors, no one had received antiviral therapy, 4/5 were treated with antibiotics before they were hospitalized. One patient had nosocomial infection. Patients were admitted to the hospital on the 3rd to 8th day of the disease. They received oseltamivir treatment on the 4th to 9th day. All patients developed pneumonia complicated by acute respiratory distress syndrome. Death appeared between the 4th and 27th day after the onset of symptoms. Autopsies were performed in 5 cases and revealed haemorrhagic pneumonia in 2 patients.Conclusion: Delayed diagnosis and antiviral treatment initiation has a significant impact on mortality in A (H1N1) influenza. During the influenza epidemic, patients presenting typical symptoms should always be suspected of having influenza. Antiviral treatment has to be initiated immediately, especially ifthere are risk factors of severe disease.
Authors and Affiliations
Marta Rorat, Tomasz Jurek, Ernest Kuchar, Leszek Szenborn
Keywords
Related Articles
- EP ID EP66966
- DOI -
- Views 157
- Downloads 0
Antygeny układu grupowego Duffy: budowa, właściwości serologiczne i funkcja
Antygeny układu grupowego Duffy (Fy) są umiejscowione na glikoproteinie, która siedmiokrotnie przenika przez błonę komórkową i jest obecna na powierzchni krwinek czerwonych i komórek śródbłonka niektórych narządów. Białk...
Role of prometastatic factors in gastric cancer development
The second half of the 20th century has seen a sharp worldwide decline in both the incidence and mortality of gastric cancer. Despite this, gastric cancer is the most common cause of mortality in the world. It is closely...
Salmonellozy RAS jako ważny problem epidemiologiczny
Salmonellosis is a serious health problem throughout the world. It is the most common form of food poisoning. One of the reservoirs of Salmonella are reptiles, which are increasingly kept as pets. Most reptiles are asymp...
Molekularne i cytogenetyczne podstawy rozwoju mięśniaków macicy
Mięśniaki macicy są jedną z najczęstszych niezłośliwych zmian rozrostowych dotyczących narządu płciowego u kobiet. Epidemiologia tego schorzenia często jest niemożliwa do oceny, gdyż znaczny odsetek mięśniaków macicy, to...
Epigenetyka a etiologia chorób neurodegeneracyjnych
Kluczem do morfologicznego i funkcjonalnego zróżnicowania komórek w obrębie ludzkiego organizmu jest ustalanie specyficznych wzorców ekspresji genów. Genom ludzki zawiera około 25–30 tys. genów, przy czym w każdej komórc...