The Clinical Significance of a Low Percentage of Mature Oocytes Retrieved Using Common Ovarian Stimulation Protocols.
Journal Title: Journal of Fertility Biomarkers - Year 2017, Vol 1, Issue 1
Abstract
The objective of this study was to investigate whether percentage of mature oocytes retrieved from ovaries stimulated with long agonist or multi-dose antagonist protocols affect the implantation, clinical pregnancy and live birth of ICSI (Intracytoplasmic sperm injection) cycles. The 654 cycles of agonist (long lupron) and 610 cycles of multi-dose flexible antagonist (antagon) were analyzed after stratification according to the percentage of the mature oocytes retrieved. The clinical pregnancy of the groups with less than 30 % mature oocytes retrieved, both antagonist and agonist protocol was statistically lower (at least p< 0.05) compared to the groups with more than 30% mature oocytes retrieved. In the agonist protocol, the implantation and live births for this group were significantly (p<0.009) lower than in the group with ≥70% mature oocytes retrieved. The live births in groups with more mature oocytes retrieved (30-69% and ≥70 %) of the antagonist protocol were lower (22.2% vs. 35.9% and 23.9% vs. 41.5%, p<0.0001, respectively) compare to the agonist protocol.
Authors and Affiliations
Teresa Wiesak, Robert Milewski, Stephen George Somkuti
Keywords
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- EP ID EP263198
- DOI 10.14302/issn.2576-2818.jfb-17-1435
- Views 121
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