The Clinical Significance of Ursodeoxycholic Acid in Treatment of Acute Viral Hepatitis Accompanied by Cholestasis Syndrome in Children
Journal Title: Здоров`я дитини - Year 2015, Vol 5, Issue 65
Abstract
Purpose of the study. Іmproving the treatment of acute viral hepatitis in children accompanied by cholestasis. Material and methods. We observed 40 children with acute viral hepatitis type A and B aged from 4 months old to 18 years old. The patients were randomized into 2 groups: the first group of children (a control one, n = 27) received basic therapy of acute viral hepatitis, the children of the second group (a main one, n = 13) received basic therapy of acute viral hepatitis in combination with the ursodeoxycholic acid. There was used the drug of ursodeoxycholic acid of domestic production under the trade name Ukrliv® suspension. Results of the study. 82.5 % of children with acute viral hepatitis were found to have cholestasis syndrome. The treatment of diseases accompanied by cholestasis with ursodeoxycholic acid promotes to more rapid regression of the main symptoms of acute viral hepatitis and normalization of biochemical parameters of liver functioning (ALT, alkaline phosphatase, GGT).
Authors and Affiliations
S. O. Kramariov, I. V. Shpak, A. I. Markov
Keywords
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