THE COMBINATION OF α-LIPOIC ACID INTAKE WITH ECCENTRIC EXERCISE MODULATES ERYTHROPOIETIN RELEASE
Journal Title: Biology of Sport - Year 2014, Vol 31, Issue 3
Abstract
The generation of reactive nitrogen/oxygen species (RN/OS) represents an important mechanism in erythropoietin (EPO) expression and skeletal muscle adaptation to physical and metabolic stress. RN/OS generation can be modulated by intense exercise and nutrition supplements such as α-lipoic acid, which demonstrates both anti- and pro-oxidative action. The study was designed to show the changes in the haematological response through the combination of α-lipoic acid intake with running eccentric exercise. Sixteen healthy young males participated in the randomised and placebo-controlled study. The exercise trial involved a 90-min run followed by a 15-min eccentric phase at 65% VO2max (-10% gradient). It significantly increased serum concentrations of nitric oxide (NO), hydrogen peroxide (H2O2) and pro-oxidative products such as 8-isoprostanes (8-iso), lipid peroxides (LPO) and protein carbonyls (PC). α-Lipoic acid intake (Thiogamma: 1200 mg daily for 10 days prior to exercise) resulted in a 2-fold elevation of serum H2O2 concentration before exercise, but it prevented the generation of NO, 8-iso, LPO and PC at 20 min, 24 h, and 48 h after exercise. α-Lipoic acid also elevated serum EPO level, which highly correlated with NO/H2O2 ratio (r=0.718, P<0.01). Serum total creatine kinase (CK) activity, as a marker of muscle damage, reached a peak at 24 h after exercise (placebo 732 ± 207 IU · L[sup]-1[/sup], α-lipoic acid 481 ± 103 IU · L[sup]-1[/sup]), and correlated with EPO (r = 0.478, P<0.01) in the α-lipoic acid group. In conclusion, the intake of high α-lipoic acid modulates RN/OS generation, enhances EPO release and reduces muscle damage after running eccentric exercise.
Authors and Affiliations
Barbara Morawin, Dariusz Turowski, Mariusz Naczk, Idzi Siatkowski, Agnieszka Zembron-Lacny
Keywords
Related Articles
- EP ID EP59206
- DOI -
- Views 100
- Downloads 0
Self- image as a performer in perception of the steroid “beneficiaries”
The aim of the present study was to assess differences between the current and former users of anabolic steroids (AS) and the control subjects in the following cognitive processes describing one’s self-image as a perform...
The influence of the allometric scale on the relationship between running economy and biomechanical variables in distance runners
Studies have demonstrated the need for the use of parameters that diminish the effect of body mass, for intra and inter group comparison, in individuals with different masses in order to provide a different analysis on t...
Plasma growth hormone, cortisol and testosterone responses to repeated and intermittent ergometer exercise at different pedalling rates.
The aim of this work was the evaluation of the hormonal response to the repeated and intermittent exercises at different rates. Nine students of the physical education (age: 24.1±0.39 years; body mass: 81.2±10.17kg; heig...
The effects of cognitive anxiety on the biomechanical characteristics of the golf swing
The aim of this study was to examine the effect of cognitive anxiety (CA) on the biomechanical characteristics of the golf swing. Written informed consent was obtained from 9 subjects, with a range of golf experience (ha...
DIURNAL VARIATION OF HAEMOSTATIC RESPONSE TO EXERCISE IN YOUNG SEDENTARY MALES
The aim of this study was to evaluate diurnal variations in the haemostatic response to submaximal exercise performed by young, sedentary men. Fifteen healthy young sedentary males aged 25.6 ± 1.34 (mean ± SD) years perf...