The combination of zinc and glibenclamide limits cardiovascular complications in diabetic rats via multiple mechanisms
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 2
Abstract
Cardiovascular complications have become a major cause of mortality for diabetic patients. Glibenclamide is an effective hypoglycemic agent, but failed to alleviate diabetic complications. This study aimed to evaluate whether the addition of zinc to glibenclamide could mitigate such complications. Diabetes was induced using streptozotocin (60 mg/kg, i.p.). Cardiovascular complications were detected by the significant rise of cardiac enzymes, serum lipids, myocardial oxidative stress and cardiac levels of tumor necrosis factor-α (TNF-α, a marker for inflammation) as well as massive histological changes in the heart wall in diabetic control compared to non-diabetic group. Levels of serum nitric oxide and cardiac vascular endothelial growth factor (VEGF, an angiogenic marker) were lower in diabetic rats. Addition of zinc sulfate (30mg/kg) to glibenclamide (600µg/kg) resulted in significant improvement in cardiac 0.001), in addition tobiomarkers, oxidative status and serum lipids. Highly significant reduction in cardiac TNF-α (P 0.01) were observed. Cellular infiltration and myocardial edema0.05) and VEGF (Psignificant rise in nitric oxide (P were ameliorated. These results suggest that a combined treatment of zinc and glibenclamide might be a potential therapy for preventing the risk of cardiovascular complications and reducing the mortality rate among diabetic patients.
Authors and Affiliations
Hala Attia , Nouf Al-Rasheed , Nawal Al-Rasheed , Laila Faddah
Keywords
Related Articles
- EP ID EP153100
- DOI -
- Views 95
- Downloads 0
Phenolic composition and antioxidant activity of thedifferent extracts from Thymus longicaulis C Presl. subsp. longicaulis var. longicaulis and T. longicaulis C. Presl. su bsp. longicaulis var. subisophyllus growing in Turkey
The objectives of the present study were to investigate the phenolic composition and in vitro antioxidant capacities of the infusions and different extracts of two Thymus taxa: Thymus longicaulis C. Presl. subsp. l...
Hematological screening of heavy metals among patients of asthma using medicinal herbs in Karachi, Pakistan
Prevalence and concentration of some toxic (Pb, Cd, and As) and essential metals (Zn, Cu, Cr, Ni, and Co) were determined in the blood samples collected from asthmatic patients in Karachi, Pakistan using atomic abs...
Preliminary assessment of phytochemical contents and antioxidant properties of Pistacia integerrima fruit
Present study was focused on the evaluation of preliminary phytochemical screening and antioxidant properties in hydrophilic and lipophilic solvents extracts of Pistacia integerrima fruit, collected from Lesser Him...
The effects of Cosmos caudatus (Ulam Raja) supplementation on bone biochemical parameters in ovariectomized rats
Cosmos caudatus (ulam raja) contains high mineral content and possesses high antioxidant activity which may be beneficial in bone disorder such as postmenopausal osteoporosis. The effects of C. caudatus on bone me...
Vasorelaxant effect of essential oil isolated from Nigella sativa L. seeds in rat aorta: Proposed mechanism
The effect of the essential oil extracted from Nigella sativa (L.) seeds (Nigella oil) was investigated for its vasorelaxant activity on isolated rat aorta. Nigella oil at concentrations of 10-100µg/mL elicited a d...