The Comparison α-Blocker+M3 Selective Anti-Muscarinic Combined Therapy and α-Blocker Monotherapy
Journal Title: Journal of Clinical and Analytical Medicine - Year 2012, Vol 3, Issue 1
Abstract
Aim: Effectiveness and reliability comparison of alpha-blocker monotherapy (doksazosin) and combined alpha-blocker+M3 selective antimuscarinic (doksazosin+darifenacin) treatments on male patients with Benign prostate hyperplasia and accompanying OAB (overactive bladder) symptoms. Material and Method: 101 patients with ages 50 and above who had LUTS (Lower urinary tract symptoms) complaints were included in the study. Patients were randomly organized into two groups. One group had treatment with 4mg doksazosin, the other group had 4mg doksazosin combined with 7.5mg darifenacin. Patients were evaluated in accordance with BPH manuals of EUA (European Urology Association) and AUA (American Urology Association). Patients were re-evaluated on 12th week after the treatment. International prostate symptom scores (IPSS), IPSS quality of life scores (IPSS-QoL), maximum urine flow rate (Qmax), average urine flow rates (AFR) and PVR (Post Voiding Residual Volume) data were obtained before and after the treatment from all patients. Results: Patients who received combined treatment had experienced considerable drop (p<0.01) in total IPSS and IPSS-QoL scores compared to monotherapy group. Qmax and and AFR data were found nearly equal (p=0.732). Considerable increase (p<0.01) in PVR (>43ml) in combined treatment group was observed. Discussion: Alpha-blocker+M3 selective antimuscarinic combined treatment is more effective than alpha-blocker monotherapy on male patients with LUTS secondary to BPH and OAB. However combined treatment causes considerable increase in PVR.
Authors and Affiliations
Cavit Ceylan, Kemal Ertaş, Serkan Doğan, Zeki Ender
Keywords
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- EP ID EP150749
- DOI 10.4328/JCAM.498
- Views 112
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