The component composition and antimicrobal activity of the essential oil from inflorescences of Tagetes erecta L.
Journal Title: Фармацевтичний журнал - Year 2014, Vol 1, Issue 1
Abstract
Tagetes erecta L. is the promising materials for new medicines. The study of composition of Tagetes erecta L. is of great practical and scientific importance. The aim of this scientific work is the determinate of physico-chemical properties, quantitative content and composition of the essential oil from inflorescences of Tagetes erecta plena L. var.«Havii» and its antimicrobial and antifungal activity. As object of our study we choose the essential oil from inflorescences of Tagetes erecta plena L. var. «Havaji». Plant material was harvested during the flowering period in 2013. The essential oil was obtained from inflorescences by Clevenger method. We identified components of the essential oil and determinate there quantitative content by GLC method by «Agilent Technology 6890 N» chromatograph. Chromatograms were identified by NIST02 mass-spectra library. We studied antimicrobial activity by agar diffusion method with using the paper discs. We set physical-chemical properties of the essential oil from inflorescences of Tagetes erecta plena L. var. «Havaii». Also we discovered that there are to 18 compounds in the composition of the essential oil. The quantitative content of these components was determinate. Also we discovered that 6 of these compounds were first detected. We identified, that the main compounds of the essential oil are: piperitenon (300,3 ± 0,87 mg/kg), piperiton (211,10 ± 0,61 mg/kg) spatulenol (211,10 ± 0,61 mg/kg), p-cymene-8-ol (154,20 ± 0,45 mg/kg), nonakozan (81,10 ± 0,22 mg/kg), trikozan (60,50 ± 0,17 mg/kg), heptakozan (52,90 ± 0,15 mg/kg). The amount of the essential oil from inflorescences of Tagetes erecta plena L. varieties «Hawii» was 0,5 ± 0,04%. We determinate, that the essential oil from inflorescences of Tagetes erecta plena L. var. «Havaii» has antimicrobic and antifungal activity against Staphylococcus aureus (АТСС-25923), Staphylococcus aureus (clin.), Klepsiella pneumonia (clin.), Staphylococcus saprophytus (clin.), Candida albicans (АТСС-885653) (clin.).
Authors and Affiliations
E. А. Malugina, А. V. Mazulin, G. P. Smoylovskaya, G. V. Mazulin
Keywords
Related Articles
- EP ID EP587472
- DOI -
- Views 48
- Downloads 0
Decametoxin and chlorhexidin at the domestic pharmaceutical market
Realization of marketing researches of home pharmaceutical market in the presence of drugs farmakotherapeutic group always is actual, as he allows to find out gap-fillingness of market of medications. The aim of this ana...
The analgesic activity research for the derivatives of 4-R-3-(morpholinomethylene)-1,2,4-triazole-5-thioles
Pain is a protective reaction of the organism, which is the first sign of illness or signal of danger. Existing drugs for pain reducing exhibits a series of side effects. However, with an analgesic effect, most of these...
Analysis of the availability of medicines for the treatment of servicemen with injury and wound of the brain
The most important areas that determine the effectiveness of the medical support system at all stages of providing medical assistance to servicemen is the rational use and availability of medicines and pharmaceutical ass...
Synthesis of some new thiazolo[4,5-b]pyridin-2-ones and research of their anti-inflammatory activity
In modern theoretical and clinical medicine inflammation problem remains one of the main.Deregulation of inflammatory processes leads to specific pathologies.There is a significant amount of drugs used to treat inflammat...
Modelling toxicity biologically active derivatives amides of pyridine carboxylic acids
At the present time attention is directed search for effective and non- toxic biologically active compounds. For search effective substances with the set properties requires thorough analysis and theoretical studies of p...