The concept of biologically active microporous engineering materials and composite biological-engineering materials for regenerative medicine and dentistry
Journal Title: Archives of Materials Science and Engineering - Year 2016, Vol 80, Issue 2
Abstract
Purpose: The concept presented in this study proposes indirect solutions, both, rigid onesinvolving high strength and transmission of high mechanical loads, and ones which areelastic, thin and light as fog, when a very light dressing supplying living cells is applied to anextensive wound, e.g. on skin, in a way ensuring their fast fusion with the defected surfaceof body. They are proposed implant-scaffolds, i.e. rigid devices composed of a solid metalcore and a surface or transition porous zone into which living cells may grow. The poresare so small that hair or even a very thin needle can be placed there. The interior of suchopenings, extending along the entire part of material, needs to be covered from the insidewith a very thin coating which can be accepted by living cells so that they can develop insuch conditions and penetrate such openings deep inside.Design/methodology/approach: The material solutions proposed in the study resultfrom a synergy of methods of technical sciences, including materials engineering andchemical sciences, in consistency with the adopted author’s assumptions, but, in particular,depending on the specificity of clinical conditions and biological sciences, also tissueengineering, in the context of medical sciences, including tissue therapy, require a multiaspectstate-of-the-art analysis and the resulting specific scientific problems which shouldbe solved and their pioneering character. Taking into consideration the lack of references inthe literature to the overall analysis of the issue, separate aspects are analysed further in thisstudy concerning biologically active cellular structures and a substrate with an engineeringcomposite material matrix used for scaffolds and newly developed implant-scaffolds.Findings: In consideration of the principal research intention of the presented researchconcept, pertaining to the development of hybrid and multilayer biological-engineeringcomposite materials, including rigid and elastic ones, composed not only of biologicallyactive cellular structures, the state-of-the-art of which is presented earlier, but also of asubstrate with an engineering material matrix, with an optimally selected type, chemicalcomposition and a nanometric structure, fulfilling a carrier function, and in fact a scaffoldfor biological structures required to have an appropriate array of mechanical properties
Authors and Affiliations
L. A. Dobrzański
Keywords
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