THE CORRELATION BETWEEN FAT INTAKE AND PLASMA SUPEROXIDE DISMUTASE ACTIVITY WITH TELOMERE LENGTH OF MINANGKABAU ETHNICITY MEN, IN WEST SUMATERA, INDONESIA
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 2
Abstract
Objective: The purpose of this research is to investigate the correlation between fat intake and plasma superoxide dismutase (SOD) enzyme activity with telomere length of Minangkabau ethnic men in West Sumatera, Indonesia. Materials and Methods: This cross-sectional study was conducted in Padang City in 2016, using a sample of 107 Minangkabau ethnic men, aged between 40 and 50 years. The total fat, saturated fatty acids (SFA), monounsaturated fatty acid (MUFA), and polyunsaturated fatty acid (PUFA) intake were collected using a food frequency questionnaire, and blood sample analysis to measure telomere length and plasma SOD activity. Results: This research indicated that an average telomere length was 584.59±305.92 bp, fat intake consists of total fat was 27.01±6.68% calorie, SFA was 24,7510.07% calorie, MUFA was 10.24±5.41% calorie, and PUFA was 7.35±3.54% calorie. Average of plasma SOD activity was 5.85±3.41 u/mL. There were no correlations between fat intake (total fat, SFA, MUFA, and PUFA) with telomere length (p>0.05), but there was a significant positive correlation between plasma SOD enzyme activity with telomere length (r=−0.202, p=0.037). Conclusion: Fat intake within normal limits does not correlate with telomere length, and plasma SOD activity is a risk factor for telomere shortening in ethnic Minangkabau men.
Authors and Affiliations
AFRIWARDI AFRIWARDI, DELMI SULASTRI, YUNIAR LESTARI, DESMAWATI DESMAWATI, PRIMA MINERVA
Keywords
Related Articles
- EP ID EP608782
- DOI -
- Views 132
- Downloads 0
DYNAMICS OF REALIZATION OF FIVE BASIC THERAPEUTIC CLASSES OF ANTIHYPERTENSIVE DRUGS IN THE FAR EAST OF RUSSIA
ABSTRACT
ASSESSMENT OF PREVALENCE OF DEPRESSION IN CARDIAC PATIENTS AND ITS ASSOCIATION WITH THE USE OF BETA-BLOCKERS AND STATINS
Objective: The objective of the study is to assess the prevalence of depression among patients with cardiovascular disease and its association with the use of β-blockers and statins.Methods: This is a prospective observ...
ANTIBACTERIAL ACTIVITY OF ANNONA SQUAMOSA L. AND ANNONA RETICULATA L. AGAINST CLINICAL ISOLATES OF MUTANS STREPTOCOCCI THE CAUSATIVE AGENTS OF DENTAL CARIES
ABSTRACTObjective: Evaluation of antibacterial activity of Annona squamosa L and Annona reticulata L against Streptococcus mutans and Streptococcus sobrinus(mutans streptococci MS) the causative agent of dental caries.Me...
GAS CHROMATOGRAPHY-MASS SPECTROMETRIC ANALYSIS AND IDENTIFICATION OF BIOACTIVE CONSTITUENTS OF CATHARANTHUS ROSEUS AND ITS ANTIOXIDANT ACTIVITY
Objective: The main objectives of this study were analysis of the phytochemicals produced by two different Catharanthus roseus morphotypes, i.e., pink and white flowered and evaluate it morphologically and phytochemicall...
IDENTIFICATION OF FUNCTIONAL SNPs OF MDR1 GENE AMONG NEPHROTIC SYNDROME CHILDREN IN SOUTH INDIA
Objective: This study was conducted to determine the frequency of C3435T and G2677T/C single nucleotide polymorphisms of multi drug resistancegene -1 (MDR1) in nephrotic syndrome (NS) children in relation to healthy subj...