The Correlation between the Plasma Level of NT-Pro BNP and Left Ventricular Diastolic Dysfunction
Journal Title: International Journal of Cardiology and Research (IJCRR) - Year 2015, Vol 2, Issue 5
Abstract
Objective: To study the correlation between plasma level of N-terminal pro-BNP and left ventricular diastolic dysfunction in asymptomatic patients. Methods: The study included 35 patients divided into control group: included 10 patients with normal systolic and diastolic function and patient group: included 25 patients with normal systolic and asymptomatic diastolic dysfunction. The patients were evaluated by conventional echocardiography (diameters, systolic and diastolic function) and tissue Doppler (early diastolic velocity) then E/e` was measured. Serum pro BNP was measured and correlated with demographic and echocardiographic parameters and its sensitivity, specificity were evaluated. Results: Both groups were of comparable age, gender, BMI, risk factors and systolic function. By Doppler echocardiography there was no difference in E velocity between two groups (0.64+0.18 m/sec Vs 0.67+0.14 P = 0.302), but by tissue Doppler there was significant difference in the mean value of e` velocity (m/sec) (0.14+0.06 Vs 0.06+0.01 P=0.001) and E/eˋ (5.03+0.149 Vs 0.55+1.79 P= 0.001). There was significant difference between two groups according to serum NT pro BNP (ng/ml) was (59.1) in the control group Vs (154.1) in patient group (P = 0.001). There was significant correlation between serum NT pro BNP and E (P= 0.001) and E/e` (P = 0.001). The sensitivity of serum NT Pro BNP was 94.2, specificity was 88.1, positive predictive value was 90.6 and its accuracy was 86.2. Conclusion: Serum level of NT pro BNP can be used as innovative method in predicting asymptomatic diastolic dysfunction nand so prevent the progression to symptomatic diastolic heart failure.
Authors and Affiliations
Shaimaa Ahmed Mostafa
Keywords
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- EP ID EP206493
- DOI 10.19070/2470-4563-1500010
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