The Coulter Principle for Analysis of Subvisible Particles in Protein Formulations
Journal Title: The AAPS Journal - Year 2011, Vol 13, Issue 1
Abstract
The Coulter principle can be used for analysis of subvisible particles in protein formulations. The approach has several advantages including: an orthogonal operating principle, high sensitivity, ability to detect very small particles, excellent reproducibility, and high-resolution size information. This minireview discusses some of the important considerations that must be taken into account when utilizing the Coulter principle for subvisible particle analysis in protein formulations.
Authors and Affiliations
Matthew N. Rhyner
Keywords
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