The Crosstalk between Interferon and Transforming Growth Factor Beta Signaling Pathways in Hepatitis C Patients
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 10
Abstract
<strong>Background: </strong>there is an increasing interest in using microRNAs (miRNAs) as biomarkers in liver disease. Diagnostic biomarkers in hepatitis C serve as a great benefit for the early treatment of HCV.<strong> Aim of the Work:</strong> the aim of this study was to evaluate the expression of miRNA-16 in Egyptian patients infected with HCV and their relation to different biochemical and clinicopathological parameters.<strong> Patients and Methods:</strong> twenty-five subjects were chosen, 16 HCV infected and 9 healthy controls. Collection, processing and storage of serum for evaluation of miRNA16 using RT-qPCR was done. We evaluated the power of miRNA as a diagnostic tool using ROC curve analysis. The prognostic significance of the investigated parameters in HCV patients was explored.<strong> Results:</strong> there is a highly significant difference of miRNA 16 expression between HCV patients and healthy controls. miRNA 16 has great sensitivity and specificity for differentiating between patients with HCV and healthy controls.<strong> Conclusion: </strong>miRNA 16 can be used as a potential diagnostic biomarker for HCV. In addition, it could be used for staging of the disease.
Authors and Affiliations
Eman Helal
Keywords
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- EP ID EP584336
- DOI 10.12816/ejhm.2018.11278
- Views 118
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