The Crosstalk between Interferon and Transforming Growth Factor Beta Signaling Pathways in Hepatitis C Patients
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 10
Abstract
<strong>Background: </strong>there is an increasing interest in using microRNAs (miRNAs) as biomarkers in liver disease. Diagnostic biomarkers in hepatitis C serve as a great benefit for the early treatment of HCV.<strong> Aim of the Work:</strong> the aim of this study was to evaluate the expression of miRNA-16 in Egyptian patients infected with HCV and their relation to different biochemical and clinicopathological parameters.<strong> Patients and Methods:</strong> twenty-five subjects were chosen, 16 HCV infected and 9 healthy controls. Collection, processing and storage of serum for evaluation of miRNA16 using RT-qPCR was done. We evaluated the power of miRNA as a diagnostic tool using ROC curve analysis. The prognostic significance of the investigated parameters in HCV patients was explored.<strong> Results:</strong> there is a highly significant difference of miRNA 16 expression between HCV patients and healthy controls. miRNA 16 has great sensitivity and specificity for differentiating between patients with HCV and healthy controls.<strong> Conclusion: </strong>miRNA 16 can be used as a potential diagnostic biomarker for HCV. In addition, it could be used for staging of the disease.
Authors and Affiliations
Eman Helal
Pattern of Thyroid Diseases in Arar City, Northern Saudi Arabia
<strong>Background:</strong> Thyroid hormone acts as a vital factor of development and growth, and in adults plays a critical part in the regulation of the function and metabolism of virtually every organ system. <strong...
Intracytoplasmic Sperm Injection Outcome in Patient at Risk of Poor Responder Using Mild Ovarian Stimulation Protocol versus Short Gonadotropin Releasing Hormone Agonist Protocol
<span>Background: </span><span>Poor ovarian response to stimulation in IVF cycles is a challenging and frustrating condition for both clinician and patient, due to its poor prognosis in terms of pregnancies and live birt...
Association between Cretinism and Prolactin Secretion
<strong>Objective:</strong>To compare the serum prolactin level in hyperthyroid and normal control females. Hyperthyroidism is a mutual disease. Even though a direct relation has been demonstrated amid hypothyroidism and...
Relationship between Diabetic Retinopathy and Methylenetetrahydrofolate Reductase Gene Polymorphism
Purpose: To assess MTHFR rs1801133 (C677T) gene polymorphism in diabetic patients as a risk factor for diabetic retinopathy and to establish the changes in Platelet indices & count in diabetic patient as compared to the...
The Role of Fibroscan as a Non-Invasive Predictor for Oesophageal Varices in Post HCV Cirrhotic Egyptian Patients With or Without Bilhariziasis
<strong>Background: </strong>Development of oesophageal varices is a major complication that may occur in up to 90% of cirrhotic patients. The endoscopic screening is an invasive procedure. This is why the selection of p...