The cytokines in inflammatory bowel disease
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2009, Vol 63, Issue
Abstract
Inflammatory bowel disease includes ulcerative colitis and Crohn’s disease. It is a group of chronic disorders of unknown etiology characterized by inflammation of the gastrointestinal tract. The etiopathogenesis of inflammatory bowel disease is multifactorial. Recent data show that the development of inflammatory bowel disease is associated with the interplay of genetic, bacterial, and environmental factors and dysregulation of the intestinal immune system. The latest research is focused on the key role of cytokines in inflammatory bowel disease. In patients with inflammatory bowel disease, a number of recruited monocytes and activated macrophages are the source of cytokines in the inflamed alimentary tract mucosa. The role of pro-inflammatory cytokines (IL-1α, IL-1β, IL-2, -6, -8, -12, -17, -23, TNF, IFN) in inflammatory bowel disease is associated with the initiation and progression of ulcerative colitis and Crohn’s disease. Anti-inflammatory cytokines (IL-4, -10, -13) also contribute to the pathogenesis of inflammatory bowel disease, decreasing the inflammatory response by down-regulating proinflammatory cytokine production.
Authors and Affiliations
Beata Polińska, Joanna Matowicka-Karna, Halina Kemona
Keywords
Related Articles
- EP ID EP66367
- DOI -
- Views 167
- Downloads 0
Czy geny KIR są związane z klinicznymi parametrami w przebiegu choroby przyzębia?
Health – promoting effect of quercetin in human diet
Quercetin is a plant flavonoid phytochemical exhibiting a broad spectrum of properties i.a. antioxidant, anti-inflammatory and immunomodulatory. However, the effect of quercetin is not clear. This compound at low concent...
Osteoartroza: etiologia, czynniki ryzyka, mechanizmy molekularne
Osteoarthritis is an incurable joint disease manifesting itself with gradually progressing degenerative changes, leading to premature motor disability. These changes mainly occur owing to an imbalance between the process...
Reptile-associated salmonellosis as an important epidemiological problem
Salmonellozy stanowią poważny problem zdrowotny na całym świecie. Są najczęstszą postacią zatruć pokarmowych. Jednym z rezerwuarów zwierzęcych pałeczek Salmonella są gady, coraz częściej hodowane jako zwierzęta domowe. W...
The influence of IGF-1 on fetal growth during pregnancy complicated by gestational diabetes mellitus
Insulin-like growth factor-1 (IGF-1) is an important part of IGF system. The structure and function of IGF-1 are similar to that of insulin. Thus, IGF-1 may participate both in the gestational diabetes mellitus (GDM) pat...