The decreasing effect of troxerutin on the level of pro-inflammatory cytokines in rats with sepsis caused by the experimental cecal puncture
Journal Title: Iranian Journal of Veterinary Science and Technology (IJVST) - Year 2021, Vol 13, Issue 2
Abstract
Sepsis is the main mortality factor in patients undergoing surgery and its treatment currently includes cardiac resuscitation and reducing the immediate risk of infection. Troxerutin is a common compound in vegetables, fruits, and seeds and has several biological activities, including anti-platelet, anti-serotonin, antioxidant, and anti-inflammatory effects. Accordingly, we hypothesized that it can decrease interleukin 1 (IL-1) and tumor necrosis factor-alpha (TNF-a) levels in the serum of rats with sepsis. Twenty-four adult male Sprague-Dawley rats were used in this study. The rats were equally and randomly divided into 3 groups: sham operation group, control group, and treatment group. Both the control and treatment groups underwent surgical cecal ligation and perforation. Troxerutin (130 mg/kg) was injected subcutaneously twice a day to the animals of the treatment group for 3 days or until the animalsâ death. Surviving rats were euthanized after 1.5 ml of blood samples were taken 3 days after the cecal ligation and perforation. IL-1 and TNF-a were measured by the blood serum ELISA assay. The differences in mortality rates were significant between the control group and the other two groups (p = 0.008). The results showed a significant increase in IL-1 and TNF-a in the control group compared to the sham group (p < 0.05). In addition, the levels in the treatment group significantly decreased compared to the control group (p < 0.05). In conclusion, our results indicate that troxerutin could increase survival in rats developing septic shock by reducing pro-inflammatory cytokines including IL-1 and TNF-a.
Authors and Affiliations
Ali Shaker,Siamak Kazemi-Darabadi,Yaser Jafari-Khataylou,
Keywords
Related Articles
- EP ID EP722368
- DOI -
- Views 37
- Downloads 1
A survey of antibiotic residues in commercial eggs in Kermanshah, Iran
Poultry nutrition or inappropriate treatments by antibiotics can lead to production of eggs with antibiotic residues. The aim of the present study is to assess the prevalence of drug residues in eggs presented in Kermans...
Detection of Ciprofloxacin resistance genes in Escherichia coli isolated from dogs with urinary tract infections
This research was performed on uropathogenic Escherichia coli (E. coli) isolates and established the genes of resistance to ciprofloxacin between the isolates. A total of one hundred and three urine samples were tested f...
A survey on Nosema apis infection in apiaries of Urmia, North-West of Iran
The microsporidium Nosema apis is a protozoan parasite specific for the epithelial cells of the ventricles of adult bees. Nosemosis occurs throughout the world. Between February and May 2002-2003, samples were randomly c...
The First Report of a Horned Owl Infection with the Trematode Plagiorchis noblei in Shahrekord, Iran
In 2022, the trematode Plagiorchis noblei was isolated from a Horned owl (Asio otus) in Shahrekord city. This trematode was isolated from the small intestine of the Horned owl. The trematode was fixed on a microscope sli...
A survey of Nosema apis infection in apiaries of North Khorasan province, Iran
Nosema apis is an obligate intracellular parasite belonging to phylum Microsporidia. This para site is known as main causative agent of nosemosis in honeybees especially in the European honeybee (Apis mellifera). Nosemos...