The detection of areas in Poland with an increased prevalence of isolated cleft lip with or without cleft palate
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2015, Vol 22, Issue 1
Abstract
[b]Introduction and objectives[/b]. It is difficult to identify the environmental factors which together influence the occurrence of congenital malformations. It could be helpful to define the geographic location of the areas with an increased prevalence of such malformations. The aim of this study is to define if there are regions in Poland where the prevalence of isolated cleft lip, with or without a cleft palate (CL±P), is increased, and to present a method for searching for such areas. [b]Materials and methods[/b]. The analysis included the whole area of Poland monitored in 2007–2008 by the Polish Register of Congenital Malformations (PRCM). The area was divided into 3,045 census regions. The number of children with CL±P in those years was 514, and the size of the reference population (live births) was 802,372. Two methods were used for the detection of clusters with an increased prevalence of isolated CL±P: the LISA analysis and Kulldorff’s scan statistic, and described in detail. [b]Results[/b]. The prevalence of isolated CL±P and the smoothed prevalence were calculated for every community. The results of the LISA and Kulldorff’s analyses were consistent. Both methods located the sites with an increased prevalence of isolated CL±P. The lack of statistical significance of clusters indicated by Kulldorff’s statistic, and the significance of clusters detected with the use of the LISA method, indicated the existence of clusters with an only slightly increased prevalence of isolated CL±P. [b]Conclusions[/b]. The study shows the usefulness of the LISA and Kulldorff’s spatial analyses in epidemiological studies, including the etiology of congenital malformations. Because the two methods work in different ways, good results can be obtained when they are used together.
Authors and Affiliations
Barbara Więckowska, Anna Materna-Kiryluk, Katarzyna Wiśniewska, Tomasz Kossowski
Keywords
Related Articles
- EP ID EP80925
- DOI -
- Views 141
- Downloads 0
Increasing role of arthropod bites in tularaemia transmission in Poland – case reports and diagnostic methods
The study describes four cases of tularaemia – one developed after contact with rabbits and three developed after an arthropod bite. Due to non-specific clinical symptoms, accurate diagnosis of tularaemia may be difficul...
Reactivation of BKV and AdV infections during post-transplant immunosuppressive therapy
Introduction. Viral infections are an important problem in transplantology. Infections in recipients may develop as a result of the original infection or reactivation of a latent infection. Many viruses have the ability...
Lipid pattern in middle-aged inhabitants of the Lower Silesian region of Poland. The PURE Poland sub-study
Introduction. A decreased serum high density lipoprotein-cholesterol (HDL-C) is a strong predictor of cardiovascular risk. However, total HDL is a very dynamic, changeable fraction, and does not perform the function of a...
Diffusion-weighted MRI of kidney in the diagnosis of clear cell renal cell carcinoma of various grades of differentiation
[b]Introduction[/b]. Renal cell carcinoma (RCC) is the most common malignant epithelial tumour of the kidney, accounting for 85–90% of all solid renal tumours in adults and comprising 1–3% of all malignant visceral neopl...
Antifungal activity of essential oils against selected terverticillate penicillia
The aim of this study was to screen 15 essential oils of selected plant species, viz. [i]Lavandula angustifolia[/i], [i]Carum carvi[/i], [i]Pinus mungo var. pulmilio[/i], [i]Mentha piperita[/i], [i]Chamomilla recutita[/i...