The Difference of Thyroid Cancer in Hyperactive Adenoma and Hyperthyroidism in Endemic Areas
Journal Title: HASEKİ TIP BÜLTENİ - Year 2019, Vol 57, Issue 3
Abstract
Aim: In recent years, dramatic changes in treatment approaches and conflicting publications on thyroid cancer have been reported from endemic regions. The probability of cancer has increased in endemic areas especially in the presence of hyperactive adenoma (HA) and/or hyperthyroidism (HT). It has been suggested that subclinical and clinical hyperthyroidism increase the risk of several solid malignancies while hypothyroidism may reduce aggressiveness or delay the onset of cancer. Methods: In this retrospective study, a total of 162 patients, who were operated for HA and/or HT between 2004 and 2009 in a training and research hospital, were compared with 332 controls who were operated for other thyroid diseases. The study group consisted of 33 patients with HA alone, 89 patients with HT alone, and 40 patients with both. Statistical analysis was performed with NCSS 2007 package program. Results: The cancer rate was 8.7% in patients with HA and 9.5% in those with HT. There was no statistically significant difference between patients with HA or HT and controls. Three of 13 patients with cancer in the study group and 13 of 26 in the control group had microinvasive papillary cancer. LDH and ALP values in the study group were statistically lower than in the control group. When compared with the control group, the diameter of dominant nodule was statistically significantly larger in the whole study group (p=0.008), in patients with HA (p=0.003) and those with HT (p=0.021). Conclusion: Cancer risk does not decrease in the presence of HA and/or HT.
Authors and Affiliations
Adnan Hut, Nurcan Güler
Keywords
Related Articles
- EP ID EP637809
- DOI 10.4274/haseki.galenos.2019.5456
- Views 78
- Downloads 0
The Place of Ultrasonography and Alvarado Scoring System in the Diagnosis of Acute Appendicitis
.
The Role of Magnetic Resonance Imaging for Evaluation of Pancreatic Lipomatosis After Bariatric Surgery
Aim: To investigate the role of non-contrast magnetic resonance imaging (MRI) and findings of quantitative MRI in the evaluation of pancreatic lipomatosis in patients undergoing bariatric surgery. Methods: Pre-operative...
Non-melanoma Skin Cancers Reported at a Secondary Care Institution in Milas
Aim: We investigated demographic features, tumor location and histopathology as well as frequency of recurrence of nonmelanoma skin cancer (NMSC) in patients in Milas region. Methods: Medical files of 120 patients with...
Investigation of Predictive Value of Complete Blood Count in the Diagnosis of Acute Complicated Appendicitis
Aim: Whether it is possible to differentiate complicated from uncomplicated acute appendicitis (AA) by using complete blood count (CBC) is controversial. In this study, we analysed the predictive value of CBC in differen...
Retroperitoneal Ancient Schwannoma
Schwannomas are benign peripheral nerve sheath tumors made up of Schwann cells. Ancient schwannoma is an uncommon subtype of schwannomas exhibiting areas of cystic cavitation, calcification and hyalinization. The “ancien...