The diluted atropine for inhibition of myopia progression in Korean children
Journal Title: International Journal of Ophthalmology - Year 2018, Vol 11, Issue 10
Abstract
"AIM: To evaluate the efficacy and safety of three different concentrations of diluted atropine for the control of myopia in Korean children, and to assess the risk factors associated with rapid myopia progression. METHODS: A total of 285 children, with refractive errors within the range of -6 diopters (D) between 5 and 14 years of age were included. After using 0.01%, or 0.025%, or 0.05% atropine, for about 1y, changes in refraction, axial lengths and frequency of adverse events were analyzed. Logistic regression analyses were performed to evaluate the risk factors associated with rapid myopia progression. RESULTS: The changes in the mean spherical equivalent values were -0.134 D/mo in the before atropine group, -0.070 D/mo in the 0.01% atropine group, -0.047 D/mo in the 0.025% atropine group, and -0.019 D/mo in the 0.05% atropine group, with significant differences between the groups (P<0.001). The axial elongation was 0.046 mm/mo, 0.037 mm/mo, 0.025 mm/mo, and 0.019 mm/mo respectively, with significant differences between the groups (P=0.003). The incidence of photophobia and near vision difficulty was not different among the three atropine groups (P=0.425 and P=0.356, respectively). Multivariate logistic regression analyses showed that only highly myopic parents were a significant predictive factor of rapid myopia progression in Korean children (odds ratio, 8.155; 95% confidence interval, 3.626-18.342; P<0.001). CONCLUSION: Treatment with 0.01%, 0.025% and 0.05% atropine solution inhibits myopia progression in Korean children in a dose-dependent manner. Children with highly myopic parents preferentially shows a rapid myopia progression rate."
Authors and Affiliations
Sun Young Shin
Keywords
Related Articles
- EP ID EP477392
- DOI 10.18240/ijo.2018.10.13
- Views 49
- Downloads 0
Comment on “Surgical management of fungal endophthalmitis resulting from fungal keratitis”
Comment
Evaluation of the safety and efficacy of therapeutic bandage contact lenses on post-cataract surgery patients
"AIM: To evaluate the safety of therapeutic bandage contact lens for post-cataract surgery patients and to illustrate its efficacy on post-operative comfort and tear-film stability. METHODS: A total of 40 participants we...
Repeatability of Ophtha Top topography and comparison with IOL-Master and LenstarLS900 in cataract patients
"AIM: To determine the repeatability of Ophtha Top topography and assess the consistency with intraocular lens (IOL)-Master and LenstarLS900 (Lenstar) in measuring corneal parameters among cataract patients. METHODS: Tot...
Role of microfluctuations in accommodation: a novel approach to reduce non-accommodative noise
Accommodative response and its possible role in myopia development has been explored through the study of the microfluctuations (MFs) of accommodation, which are commonly divided in high (1.0 to 2.3 Hz) and low (0.1 to 0...
Adenocarcinoma of the nonpigmented ciliary epithelium manifested as an anterior chamber mass
Letter