The Discovery of Insulin and the Future for Insulin Replacement Therapy
Journal Title: International Journal of Clinical Pharmacology & Toxicology(IJCPT) - Year 2012, Vol 1, Issue 1
Abstract
Adequate consumption of antioxidants, such as vitamin E, is thought to be essential for optimal health. Nutritional surveys have shown below optimal levels of vitamin E intake for adults in the United States despite a variety of dietary sources available. Fortified breakfast cereal is marketed to provide up to 100% of the daily value for several vitamins and minerals, including vitamin E, a known shortfall nutrient. The aim of the study was to determine the effect of consuming a 1-ounce serving of fortified breakfast cereal on vitamin E dietary intake as well as serum tocopherol concentrations among healthy adults. Forty-two adults completed a 6-week randomized, controlled, parallel-arm, open-label design (2-week usual diet run-in period followed by a 4-week control versus treatment period). The control group (n= 21) consumed and recorded their usual diet while the intervention group (n= 21) consumed and recorded their usual diet with the addition of a 1-ounce serving of fortified breakfast cereal during the 4-week treatment period. Diet diaries for the 6-week study period were assessed for accuracy and analyzed using Nutrient Data System for Research version 2010. Dietary and serum vitamin E (alpha-tocopherol) levels were determined. Mean total vitamin E dietary intakes at baseline were 8.0 + 5.5 mg for the intervention group and 7.8 + 4.8 mg for the control group. Total vitamin E dietary intakes increased in the intervention group to 19.5 + 5.1 mg at weeks 3 & 4 and 19.7 + 4.3 mg at weeks 5 & 6 (P<.001; P<.001) while the control group intake remained unchanged. Mean serum alpha-tocopherol levels were 0.42 + 0.31 mg/dL in the control group and 0.41 + 0.16 mg/dL in the intervention group at the baseline period. Total vitamin E dietary intakes, but not serum alpha-tocopherol, increased following the 4 weeks of fortified breakfast cereal consumption.
Authors and Affiliations
Sompop Bencharit
Keywords
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- EP ID EP194401
- DOI 10.19070/2167-910X-120001e
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