The effect of addition NaCI 150 mOsmol pH 7 on liposomes Tetraether Lipid (EPC-TEL 2,5) with sonication
Journal Title: International Journal of Current Medical Science and Dental Research - Year 2019, Vol 1, Issue 2
Abstract
As a drugs carrier, liposome can alter the pharmacokinetics of the entrapped drugs. Thus, drugs can act directly on the targeted cell while their systemic side effects are reduced. To become an effective drugs carrier, liposome must reach its stability in chemical, physical, and biological conditions. Liposome stability can be achieved by changing the lipid composition, such as EPC-TEL 2,5 which is made from the combination of Egg Yolk Phosphatydyl Coline (EPC) and TEL 2,5 mol % that is extracted from Thermoplasma acidofilum. The aim of this study is to test the chemical stability of liposome EPC-TEL 2,5 with sonication by addition of NaCI 150 mOsmol pH 7 solution. The increase in number of liposome larger than 100 nm is the stability parameter in this study. After observation at day 0, 7, 30, 60, 90, there was no significant increase in the number of liposome larger than 100 nm after addition of NaCI 150 mOsmol pH 7 compared with control.
Authors and Affiliations
Yulhasri .
Keywords
Related Articles
- EP ID EP662975
- DOI -
- Views 223
- Downloads 0
Clinical Features and Patterns of CD4+ T Lymphocyte Counts Among HIV/AIDS Patients Attending A University Teaching Hospital in North-Central Nigeria
Background:The use of CD4+ T Lymphocyte count as a vital component to ascertain the stage of HIV/AIDS disease as well as monitor the progress of the disease continues to take centre stage in the management of HIV/AIDS in...
Mental Health in South Asia:Resource Scarcity and Systemic Neglect
In population size India, Pakistan and Bangladesh comprising the Indian sub-continent are the largest in South Asia with a combined population of 1.66 billion. Although widespread poverty, natural disasters, environmenta...
The Patient Check List
In our everyday practice, when the patient attends his outpatient appointment, he/she expects a full perfect session of consultation with the expert. So, a good preparation from both parties promotes a better quality of...
Health and Health Care Financing in South Asia:Continuing Inequity?
Along with the Indian sub-continent (India, Pakistan and Bangladesh), South Asia also includes a few other smaller countries such as Afghanistan, Bhutan, Maldives, Nepal and Sri Lanka. These eight South Asian countries,...
Appropriate Use of Metered- Dose Inhalers Technique and its Determinants Among Asthmatic Adult Patients Attending Chest Clinics in Al Noor Specialist Hospital and Hera General Hospital at Makkah Al- Mukarramah, 2018
Background: The most common route for managing bronchial asthma is using inhaled medications. Correct inhaler technique requires steps performed in sequence. However, various studies have reported critical errors in the...