THE EFFECT OF APROTININ ON POSTLAMINECTOMY PERIDURAL FIBROSIS İN THE RABBIT
Journal Title: Journal of Turkish Spinal Surgery - Year 1994, Vol 5, Issue 4
Abstract
The effect of aprotinin on postlaminectomy peridurat fibrosis in 20 farm,rabbits was studied in this prelimi-nary study. Laminectomies were performed at two different level (L2 and La) in 20 rabbits. absorbable sponge soaked with aprotinin or phosphate buffered şaline (PBS) was applied in a double-blind fashion to the opera-tive sites in rabbit. Animals were killed after 2 or 4 weeks. The extent of peridural fibrosis was evaluated by gross microdissection and histological analysis. İt was shown that aprotinin reduced the peridural fibrosis after laminectomy.
Authors and Affiliations
Murat İMER, Erol YALNIZ, Sebahattin ÇOBANOĞLU, Birol YANIK, Faruk YORULMAZ, Kemal KUTLU
Keywords
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