The effect of bacterial infections in cirrhotic patients with esophageal variceal bleeding
Journal Title: Annals of Hepatology - Year 2014, Vol 13, Issue 3
Abstract
Background. Cirrhotic patients are prone to having bacterial infections due to impaired innate immunity. This nationwide population-based study aimed to identify the effect of bacterial infections on the mortality of the cirrhotic patients with esophageal variceal bleeding (EVB). Material and methods. The Taiwan National Health Insurance Database was used to collect data about the cirrhotic patients receiving endoscopic procedures for EVB between January 1, 2004 and December 31, 2004. The enrolled patients were followed up individually for one year to identify their 6-week and 1-year mortalities. Results. Of the 2,053 cirrhotic patients with EVB, 318 (15.5 %) were diagnosed with bacterial infections. Compared to non-infection group, the adjusted hazard rations (HRs) of bacterial infection for 6-week and 1-year mortalities were 2.69 (2.06-3.52) and 1.89 (1.56-2.28), espectively. Compared to non-infection group, the HRs of pneumonia, spontaneous bacterial peritonitis, urinary tract infection, and sepsis without specific focus (SWSF) were 3.54, 1.91, 1.04, and 3.95 for 6-week mortality, and 3.18, 1.52, 1.15, and 2.23 for 1-year mortality of cirrhotic patients with EVB. Conclusions. In cirrhotic patients with EVB, bacterial infections increase 2.7 folds of 6-week mortality and 1.9 folds of 1-year mortality. Of all infections, pneumonia and SWSF contributed higher risks for mortality.
Authors and Affiliations
Gan Zuo-Hua , Tsai Chen-Chi , Tseng Kuo-Chih , Hsieh Yu-Hsi , Hung Tsung-Hsing
Keywords
Related Articles
- EP ID EP78398
- DOI -
- Views 147
- Downloads 0
Juvenile hemochromatosis associated with heterozygosity for novel hemojuvelin mutations and with unknown cofactors
Background & Aims. Juvenile hemochromatosis (JH) is a rare autosomal recessive disorder characterized by severe early-onset iron overload, caused by mutations in hemojuvelin (HJV), hepcidin (HAMP), or a combi...
Geographical distribution of HCV genotypes in Mexico
Chronic hepatitis C (CHC) is the second cause of endstage liver disease in our country and one of the main indications of liver transplantation. Hepatitis C virus (HCV) genotype is the principal prognostic factor and the...
Cholestatic hepatitis C after chemotherapy containing rituximab in diffuse large B cell lymphoma
Rituximab is a chimeric anti-CD20 monoclonal antibody that is a widely used for the treatment of B cells non-Hodgkin lymphoma. The use of chemotherapy regimens containing rituximab in HCV-positive patients with non-Hodgk...
Annals of Hepatology. What is next?
The product of triglycerides and glucose as biomarker for screening simple steatosis and NASH in asymptomatic women
Introduction and aim. Given that early identification of non-alcoholic fatty liver disease (NAFLD) is an important issue for primary prevention of hepatic disease, the objectives of this study were to evaluate the effic...