The Effect of Black Garlic Extract on Levels of IL-6, TGF-β, TNF-α, IL-10, Vaginal pH, Bacterial Colonies in Pregnant Rats Aerobic Vaginitis Model
Journal Title: Jordan Journal of Pharmaceutical Sciences - Year 2022, Vol 15, Issue 4
Abstract
The purpose of this study is to prove the effect of black garlic in various doses on the levels of TNF-α, IL-10, TGF-β, IL-6, acidity (pH) of vaginal fluid, and the amount of bacterial colonization in pregnant rats (Rattus norvegicus) aerobic vaginitis model. Garlic 750 grams was heated in a magic com at 700C for 14 days, extracted by maceration method, and 3.072mL of methanol as solvent. Aerobic vaginitis model using a probe with different doses for each group respectively; 100, 120, 160 mg/mL (Body Weight). The results showed a significant effect on decreasing TNF-α levels, (r= -0.717 with sig/p= 0 0.02 < 0.05), IL-6 (decreased levels of IL-6 = 64.2% for P2 group), and a negative relationship with IL-10 (r= -0.527 with sig/ p = 0.036 < 0.05) and decreasing pH values (r = -0.797 sig/p = 0.00 < 0.05). The increase in TGF-β levels and the decrease in the number of colonies were not significant (increase in TGF-β levels = 64.2% and r = 0.295 sig/p = 0.268 > 0.05). Black garlic extract was able to reduce the pH (increase acidity) of vaginal fluids. Black garlic has an immunomodulatory activity that can significantly reduce levels of TNF-α and IL-6.
Authors and Affiliations
Tri Ratna Juita, Rezha Alivia Hildayanti, Sri Wahyuni, Kusworini Handono, Yahya Irwanto, Bambang Raharjo, Rahajeng Rahajeng, Tita Septi Handayani
Keywords
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