The Effect of Continuous Aerobic Exercise on Hyperphosphorylated Tau Protein in Diabetic Rats
Journal Title: Annals of Military and Health Sciences Research - Year 2018, Vol 16, Issue 3
Abstract
Background In neurodegenerative complications, the function and structure of the neurons undergo a change, which eventually cause the death of neurons. Objectives The purpose of this research was to determine the effect of continuous aerobic exercise on neurodegeneration in diabetic rats. Methods A total of 84 male Wistar rats were divided into four groups, including: (1) sedentary control (SC), (2) trained control (TC), (3) sedentary diabetic (SD), and (4) trained diabetic (TD). The exercise protocol in this study comprised of 12 weeks, three sessions per week. Results There was no significant difference in the level of tau protein hyperphosphorylation in four weeks of training (P = 0.128), however, there was a significant difference in the 8th and 12th weeks of training (P = 0.000). In addition, the results showed that there was a significant difference in tau protein hyperphosphorylation in different stages (4th, 8th, and 12th weeks of training) (P = 0.000). Conclusions It can be concluded that in all three different time periods (4th, 8th, and 12th weeks of training), the levels of tau protein hyperphosphorylation in the control and diabetes groups were more than those in the training, diabetes, and exercise groups. On the other hand, the higher the incidence of diabetes mellitus, and the more time gone (from 4th to 8th and then 12th week), the higher increase in the level of tau hyperphosphorylation occurred, so that continuing aerobic exercise could reduce the amount of this variable.
Authors and Affiliations
Mahnaz Omidi, Mohsen Ghanbarzadeh, Masoud Nikbakht, Abdolhamid Habibi, Rohola Ranjbar
Keywords
Related Articles
- EP ID EP430460
- DOI 10.5812/amh.85194
- Views 117
- Downloads 0
The Effect of Continuous Aerobic Exercise on Hyperphosphorylated Tau Protein in Diabetic Rats
Background In neurodegenerative complications, the function and structure of the neurons undergo a change,...
The Effects of a Short-Term High-Intensity Interval Training (HIIT) on the Levels of Serum Hypoxanthine-Guanine Phosphoribosyltransferase (HGPRT) Enzyme and Some Variables of Purine Nucleotide Cycle
Background The enzyme HGPRT 5-phosphoribosyl converts to hypoxanthine or guanine to build up IMP or GMP as an ATP and GTP precursor in the purine nucleotides salvage pathway. This...
The Effective Factors on Improving Communication Skills between Regimental Commanders and Conscripts at an Army Introductory Military Training Center
Purpose: To investigate the factors affecting communicational skills of regimental commanders toward conscripts at an army introductory military training center in Tehran. Materia...
Evaluation of Nasogastric Tube Insertion with or without Guide Wire during Laparoscopic Cholecystectomy in Imam Reza AJA Hospital
Purpose: According to frequent needs to gastric decompression by nasogastric tube insertion during laparoscopic Cholecystectomy, the current comparative study was accomplished thr...
The Role of Caregiver Burden in Quality of Life and Perception of Patients with Chronic Kidney Failure on Hemodialysis
Background Acute kidney failure is a common complication in critically ill patients of intensive care units. Objectives The objective of this study was to examine the role of care...