THE EFFECT OF DEXAMETHASONE ON POST-OPERATIVE NAUSEA AND VOMITING IN PATIENTS WHO UNDERWENT TONSILLITIS SURGERY AT THE ADESH INSTITUTE OF MEDICAL SCIENCE AND RESEARCH UNIVERSITY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2015, Vol 2, Issue 35
Abstract
PONV occurs frequently after day case tonsillectomy surgery both 5-HT3 antagonists and dexamethasone are superior to placebo in the prophylaxis of PONV in his setting. Our study has compared the efficacy of ondansetron plus dexamethasone with each anti-emetic alone for the prevention of PONV in patients undergoing day case tonsillectomy surgery. Present study was undertaken on 279 patients in the age group of 10-38yrs. Group 1 received Inj. Dexamethasone 8mg as single dose I V bolus 5 minutes before induction of anaesthesia. Group 2 received Inj. Ondansetron 4mg as single dose I V bolus 5 minutes before induction of anaesthesia. Group 3 received Inj. Ondansetron 4mg with Inj. Dexamethasone 8mg as single dose I V bolus 5 minutes before induction of anaesthesia A standard anaesthetic protocol was used in all the patients. As per our observations, the incidence of PONV in 0 – 4 hours postoperative period was statistically significant. The observations were inconclusive beyond the 4 hour period in combination group as well as either drug group. Combination of Inj. Ondansetron 4mg with Inj. Dexamethasone 8mg proved to be more efficacious over either drug alone.
Authors and Affiliations
Grace Budhiraja, Monika Gupta, Paramdeep Singh
Keywords
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- EP ID EP231807
- DOI 10.18410/jebmh/2015/746
- Views 71
- Downloads 0
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