The effect of eight weeks of aerobic training on serotonin and tryptophan hydroxylase levels in hippocampus in type 2 diabetic rats
Journal Title: مجله علمي دانشگاه علوم پزشكي كردستان - Year 2017, Vol 22, Issue 88
Abstract
Backgrounds and Aim: Aerobic exercise has proven benefits in treating and reducing the incidence of complications of chronic diseases such as diabetes. In this study we evaluated the effect of aerobic training on serotonin and tryptophan hydroxylase levels in hippocampus in type 2 diabetic rats. Materials and Methods: 30 rats were randomly divided into healthy control,diabetic control, exercise diabetic groups. 2nd and 3rd groups were made diabetic by intraperitoneal injection of streptozotocin (37mg/kg), two weeks after receiving high-fat diet. Groups of aerobic exercise performed treadmill exercise 5 times/ week for 8 weeks with duration and intensity of 55min /d and 26m/min respectively in the final weeks. 24 hours after the last exercise blood samples and hippocampus tissue samples were obtained and concentrations of serotonin (µg/g) and tryptophan hydroxylase were measured by Elisa and western blotting methods respectively. We used ANOVA and Tukey post hoc test for data analysis. Results: Statistical analysis showed that the diabetic group had significantly lower serotonin levels compared to the healthy control group (P=0.001) and exercise diabetic group (P=0.01).The mean tryptophan hydroxylase level of the diabetic groups were significantly lower than that of the healthy control group (P=0.001). The amount of tryptophan hydroxylase was significantly higher in the exercise diabetic group compared to that in the diabetic control group (P=0.001) Conclusion: In this study, diabetes led to reduction of serotonin and tryptophan hydroxylase levels in the hippocampus. Also eight weeks of aerobic exercise increased tryptophan hydroxylase level in the hippocampus of the diabetic rats.
Authors and Affiliations
PhD R Amirsasan, PhD S Dabbagh Nikokheslat, PhD P Karimi, A Esmaeili
Keywords
Related Articles
- EP ID EP282726
- DOI -
- Views 94
- Downloads 0
Prevalence of non-communicable diseases risk factors among the population of rural areas of Kurdistan Province, in Iran: A population-based study by rapid assessment method in 2015
Background and Aim: Determination of prevalence of non-communicable diseases (NCD) risk factors is the key factor for designing any intervention program for the control and prevention of these diseases. The aim of this s...
Serologic survey of Crimean-Congo hemorrhagic fever in high risk people in slaughter house, livestock owners and livestock in Kurdistan Province
Background and Aim: Crimean-Congo hemorrhagic fever (CCHF) is a tick-born zoonotic disease that can be transmitted to human by tick-bite and contact with blood, body fluids or tissues of infected animals and is associate...
The relationship between hemoglobin level in the first trimester of pregnancy and preterm delivery
Background and Aim: Anemia is the most prevalent nutritional deficiency in the world, affecting almost 30% of people worldwide, especially the pregnant women. On the other hand preterm birth is responsible for 2/3 of th...
Effect of an educational intervention based on the theory of planned behavior on the use of hearing protection devices
Background and Aim: Noise is the most common and also preventable harmful physical pollutant in the workplace in the world. Although the hearing protection devices are the last way to prevent hearing loss, most people do...
A comparative study of Doppler indices of renal artry before and after extracorporeal shock wave lithotripsy in contralateral kidney
Background and Aim: Urinary stones are considered as the third most common disorder of the urinary tract. ESWL is an effective and non-invasive treatment of urinary stones that can have adverse effects on the kidneys. Ch...