The Effect Of Etanercept Treatment On Serum Malonaldialdehyde Levels In Experimental Endometriosis Rats Model
Journal Title: Kocaeli Üniversitesi Sağlık Bilimleri Dergisi - Year 2015, Vol 1, Issue 1
Abstract
Objectives: The purpose of this study was to evaluate the serum lipid peroxidation in rats with experimental endometriosis who received etanercept (anti-tumor necrosis factor alpha) treatment. Methods: In this experimental study, 30 Wistar albino female rats were used. The surgical endometriosis model operation applied to 20 rats from those, in the 10's sham operation was performed in order to exclude the effects of anesthesia and surgery. Ectopic endometrial implants volumes of rats 4 weeks after the first operation were evaluated and blood samples were taken with a second operation. Then the rats were divided into 3 groups: Group I (did not receive any treatment, false operation, n = 10), group II (2 ml / day subcutaneous saline, endometriosis model, n = 10), group III (2 mg / kg / week etanercept subcutaneously 3 times, endometriosis model, n = 10). 3. After two weeks of treatment, ectopic endometrial implants volumes were evaluated with and second blood samples were taken from rats. Serum malondialdehyde (MDA) levels were analyzed by spectrophotometry. Results: The ectopic endometrial implant volumes of group III showed significantly lower results than group II in the post-treatment period (p =0.000). According to the same time group III implants showed significantly lower volume in the post-treatment period before the treatment (p = 0.005). In the post-treatment period, there was a significant difference between the groups in the MDA levels (p = 0.001), and group III was showed significantly lower levels of MDA compared to group II (p = 0.001). In addition, pre-treatment levels of MDA were also significantly lower compared to post-treatment period in group III (p = 0.028). Conclusion: In summary, these results suggest that etanercept has protective effects against endometriosis in rats, which may be attributed to attenuating oxidative stress.
Authors and Affiliations
Fatma Ceyla Eraldemir, Cihan Deniz Keleş, Tuğba Kum, Birol Vural, Canan Baydemir
Keywords
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