The Effect of Framingham Score on the Oncological Outcomes in Localized (T1-T2 Stage) Renal Cell Carcinoma Patients

Apply

The Effect of Framingham Score on the Oncological Outcomes in Localized (T1-T2 Stage) Renal Cell Carcinoma Patients

Journal Title: The Bulletin of Urooncology - Year 2019, Vol 18, Issue 2

Abstract

Objective: To evaluate the effect of cardiovascular disease risk on local recurrence, distant metastasis development and cancer-specific survival in patients with localized (stage 1 and 2) renal cell carcinoma (RCC). Materials and Methods: Data of patients who underwent partial or radical nephrectomy due to pathological stage 1 and 2 RCC between September 2009 and July 2016 were retrospectively evaluated. Ninety-six patients with fully accessible data were included in the study. Demographic data, histological tumor type, Fuhrman grading, local recurrence, metastasis and survival after nephrectomy were recorded. Framingham risk score, which predicts cardiovascular disease within 10 years, was calculated in all patients. The patients were divided into three groups as low (group 1), moderate (group 2) and high risk (group 3). Results: Mean age of patients was 58.66±10.55 years at the time of nephrectomy. Nine (9.4%) patients had local recurrence, 12 (12.5%) had distant metastasis and 11 (11.5%) died due to cancer during a median follow-up period of 57 (6-102) months. Regarding intergroup comparison, local recurrence rate (21.9%, p=0.012) and distant metastasis rate (25%, p=0.025) were significantly higher in group 3, and predicted recurrence-free survival (66.4 months, p=0.005), metastasis-free survival (77 months, p=0.017) and cancer-specific survival (79.9 months, p=0.024) were found to be significantly lower. In univariate analysis, body mass index, total cholesterol level, estimated glomerular filtration rate and Framingham risk score were independent predictive factors for local recurrence, distant metastasis development and cancer-specific survival. In multivariate analysis, body mass index, estimated glomerular filtration rate and Framingham risk score were more significant. Conclusion: Patients who are at high risk of developing cardiovascular disease have more local recurrence, distant metastasis and cancer-specific mortality rates, even though nephrectomy is performed due to localized RCC. Therefore, we suggest that these patients should be followed more carefully in the post-nephrectomy period.

Authors and Affiliations

İsmail Selvi , Halil Başar

Keywords

Effect of Primary Testicular Tumor Localization on Prognosis and Survival of Non-seminomatous Testis Cancer Patients

Objective: Unlike left testicular vein, right testicular vein drains into inferior vena cava. Consequently, the systemic spread of testicular cancers in each side is expected to differ based on the vascular structures of...

Comparison of Prostate Cancer Detection Rates of Cognitive Fusion-targeted Biopsy and Standard Transrectal Ultrasound-guided Biopsy

Objective: The aim of this study is to investigate whether there is a difference between standard prostate needle biopsies and cognitive fusion prostate biopsies (classical 12-core plus 2 cognitive lesions) for any prost...

EP ID EP48740
DOI 10.4274/uob.galenos.2018.1164
Views 271
Downloads 0