The effect of green tea extract on the sperm parameters and histological changes of testis in rats exposed to para-nonylphenol
Journal Title: International Journal of Reproductive BioMedicine - Year 2019, Vol 17, Issue 10
Abstract
Background: Para-nonylphenol (p-NP), an environmental contaminant, can generate free radicals that disturbs the reproductive properties. Green tea extract (GTE) is an antioxidant which may prevent the adverse effects of free radicals. Objective: The aim was to investigate the effect of GTE on sperm parameters and testis tissue in p-NP-treated rats. Materials and Methods: 24 adult male Wistar rats (215 ± 20 gr) were randomly divided into four groups (n = 6/each) – including control, p-NP (200 mg/kg/day), GTE (200 mg/kg/day), and p-NP + GTE – and orally treated for 56 days. The right testes and left caudal epididymis were used to evaluate selected parameters. In addition, the concentration of serum malondialdehyde was calculated. Results: A significant decrease in the sperm number, motility, viability and morphology (p < 0.001) was observed in the rats treated with p-NP compared to the control ones. The diameter of seminiferous tubules (p < 0.001), thickness of germinal epithelium (p = 0.018), total volume of testis (p = 0.009), volume of seminiferous tubules (p < 0.001), and testis weight (p = 0.017) decreased in the p-NP group in contrast with the other groups. Moreover, a significant increase of the malondialdehyde concentration was seen in the p-NP group when compared with the controls (p = 0.043). The majority of adverse effects of p-NP could be recovered following the administration of GTE. Conclusion: It seems GTE can be used as a potent antioxidant in the case of p-NP toxication.
Authors and Affiliations
Parisa Azizi, Malek Soleimani Mehranjani
Keywords
Related Articles
- EP ID EP671766
- DOI -
- Views 99
- Downloads 0
Low-dose hCG as trigger day and 35 hr later have different ovarian hyperstimulation syndrome occurrence in females undergoing In vitro fertilization: An RCT
Background: Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication, which can cause high morbidity and mortality. Use of gonadotropin releasing hormone (GnRH) agonist instead of human chorionic gonadotrop...
Oxidative stress and anti-oxidant defense system in Iranian women with polycystic ovary syndrome
Background: Polycystic ovary syndrome (PCOS) is a common disorder of infertility which affects more than 100 million women. It is characterized by chronic anovulation, hyper androgenism and obesity. PCOS is also associat...
Macroscopic features of the kidneys of fetuses and newborns in preeclampsia: postmortem observational study
Background: The state of the mother health is of great importance in the development of children renal pathology. Objective: To reveal macroscopic features of the fetuses and newborns kidneys of the mothers whose pregnan...
Intrauterine synechiae after myomectomy; laparotomy versus laparoscopy: Non-randomized interventional trial
Background: Leiomyomata is the most frequent gynecological neoplasm. One of the major complications of myomectomy is intrauterine adhesion (synechiae). Objective: To evaluate and compare the rate and severity of synechia...
Association between PAPP-A and placental thickness
Background: Measuring of maternal serum pregnancy-associated plasma protein-A (PAPP-A) in first trimester can be a way for early detection of adverse prenatal outcome due to faulty placenta. Objective: The aim was to Det...