The effect of NaCl 0.9% and NaCl 0.45% on sodium, chloride, and acid–base balance in a PICU population
Journal Title: Jornal de Pediatria - Year 2015, Vol 91, Issue 5
Abstract
Objectives To study the effect of two intravenous maintenance fluids on plasma sodium (Na), and acid–base balance in pediatric intensive care patients during the first 24h of hospitalization. Methods A prospective randomized controlled study was performed, which allocated 233 patients to groups: (A) NaCl 0.9% or (B) NaCl 0.45%. Patients were aged 1 day to 18 years, had normal electrolyte concentrations, and suffered an acute insult (medical/surgical). Main outcome measured: change in plasma sodium. Parametric tests: t-tests, ANOVA, X2 statistical significance level was set at α=0.05. Results Group A (n=130): serum Na increased by 2.91 (±3.9)mmol/L at 24h (p<0.01); 2% patients had Na higher than 150mmol/L. Mean urinary Na: 106.6 (±56.8)mmol/L. No change in pH at 0 and 24h. Group B (n=103): serum Na did not display statistically significant changes. Fifteen percent of the patients had Na<135mmol/L at 24h. The two fluids had different effects on respiratory and post-operative situations. Conclusions The use of saline 0.9% was associated with a lower incidence of electrolyte disturbances.
Authors and Affiliations
Helena Almeida
Keywords
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- EP ID EP556147
- DOI 10.1016/j.jped.2014.12.003
- Views 36
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